Small molecules from natural sources, targeting signaling pathways in diabetes | |
Liu, Qiong; Chen, Lili; Hu, Lihong; Guo, Yuewei; Shen, Xu | |
刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS |
2010-10 | |
卷号 | 1799期号:10-12页码:854-865 |
关键词 | Natural product Diabetes Insulin AMP-activated protein kinase Endoplasmic reticulum stress |
ISSN号 | 1874-9399 |
DOI | 10.1016/j.bbagrm.2010.06.004 |
文献子类 | Review |
英文摘要 | Diabetes mellitus (DM) is a metabolic disease caused by genetic or environmental factors. It has rendered a severe menace to the middle-aged and elderly, while there is still lack of efficient drugs against this disease. The pathogenic mechanism for DM is complex, and the complicated networks related to this disease involve distinct signaling pathways. Currently, discovery of potential modulators targeting these pathways has become a potent approach for anti-diabetic drug lead compound development. Compared with synthetic compounds, natural products provide inherent larger-scale structural diversity and have been the major resource of bioactive agents for new drug discovery. To date, more and more active components from plants or marine organisms have been reported to regulate diabetic pathophysiological signaling pathways and exhibit anti-diabetic activity. This review will summarize the regulation of natural small molecules on some key signaling pathways involved in DM. These pathways include insulin signaling pathway, carbohydrate metabolism pathway, the pathways involving insulin secretion and PPAR regulation, endoplasmic reticulum (ER) stress and inflammation related pathways and chromatin modification pathways. (C) 2010 Elsevier B.V. All rights reserved. |
资助项目 | State Key Program of Basic Research of China[2010CB912501] ; State Key Program of Basic Research of China[2007AA02Z147] ; National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[30801415] ; National Natural Science Foundation of China[30890044] ; National Natural Science Foundation of China[20721003] ; Key New Drug Creation and Manufacturing Program[2009ZX09301-001] ; Shanghai Rising-Star Program[09QA1406800] |
WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; ACTIVATED PROTEIN-KINASE ; OCCURRING PENTACYCLIC TRITERPENES ; TYROSINE-PHOSPHATASE 1B ; INDUCED XBP1 ACTIVATION ; NF-KAPPA-B ; ER STRESS ; GLYCOGEN-PHOSPHORYLASE ; INSULIN-RESISTANCE ; OLEANOLIC ACID |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000285816500018 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/278754] |
专题 | 生物技术药物研发中心(筹) 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第三研究室 |
通讯作者 | Chen, Lili |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Qiong,Chen, Lili,Hu, Lihong,et al. Small molecules from natural sources, targeting signaling pathways in diabetes[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2010,1799(10-12):854-865. |
APA | Liu, Qiong,Chen, Lili,Hu, Lihong,Guo, Yuewei,&Shen, Xu.(2010).Small molecules from natural sources, targeting signaling pathways in diabetes.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1799(10-12),854-865. |
MLA | Liu, Qiong,et al."Small molecules from natural sources, targeting signaling pathways in diabetes".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1799.10-12(2010):854-865. |
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