Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities

doi:10.1016/j.tet.2010.09.036

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	Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities
	Du, Lin 1; Li, Dehai 1; Zhang, Guojian 1; Zhu, Tianjiao 1; Ai, Jing2 ; Gu, Qianqun 1
刊名	TETRAHEDRON
	2010-11-20
卷号	66 期号:47 页码:9286-9290
关键词	Penicillium citrinum Citrinin Polyketide Cytotoxicity Cell cycle arrest
ISSN号	0040-4020
DOI	10.1016/j.tet.2010.09.036
文献子类	Article
英文摘要	Three novel carbon-bridged citrinin dimers dicitrinones A-C (1-3) were Isolated from a volcano ash-derived fungus Penicillium citrinum Their structures were elucidated by spectroscopic methods Dicitrinone A (1) and B (2) are two atropisomeric mixtures which were verified by both NMR and quantum chemical calculations Their cytotoxicity against four tumor cell lines (HL-60 MOLT-4 A-549 and BEL-7402) was evaluated by SRB and mu methods Dicitrinone B (2) arrested the HL-60 cell cycle at the G2/M phase which was analyzed using flow cytometry (C) 2010 Elsevier Ltd All rights reserved
资助项目	Natural Science Foundation of China[30973627] ; Natural Science Foundation of China[30772640] ; State Key Laboratory of Drug Research Fund[SIMM0901KF-05]
WOS关键词	DENSITY ; APOPTOSIS ; MECHANISM ; ASSAY
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000284499400026
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278718]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Gu, Qianqun
作者单位	1.Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Du, Lin,Li, Dehai,Zhang, Guojian,et al. Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities[J]. TETRAHEDRON,2010,66(47):9286-9290.
APA	Du, Lin,Li, Dehai,Zhang, Guojian,Zhu, Tianjiao,Ai, Jing,&Gu, Qianqun.(2010).Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities.TETRAHEDRON,66(47),9286-9290.
MLA	Du, Lin,et al."Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities".TETRAHEDRON 66.47(2010):9286-9290.