Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells

doi:10.1039/c1ob06094e

	Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells
	Ding, Derong; Zhang, Baozi; Meng, Tao; Ma, Ying; Wang, Xin; Peng, Hongli; Shen, Jingkang
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2011
卷号	9 期号:21 页码:7287-7291
ISSN号	1477-0520
DOI	10.1039/c1ob06094e
文献子类	Article
英文摘要	Studies on the anti-proliferative activities of novel baicalein derivatives demonstrated that compounds 8 and 9 were able to activate AMPK by enhancing the levels of phosphorylated AMPK alpha, and showed more potent anti-proliferative effects than baicalein and AICAR in A431, SK-OV-3, DU 145 and HeLa cells, suggesting an alternative therapeutic approach for benzyl baicalein in cancer therapy.
资助项目	National Natural Science Foundation of China[81172921] ; 863 Program (the National High Technology Research and Development Program of China)[2007AA02Z308]
WOS关键词	SCUTELLARIA-BAICALENSIS ; IN-VITRO ; METABOLIC-DISORDERS ; CANCER CELLS ; INHIBITION ; CARCINOMA ; FLAVONES ; GROWTH ; ENERGY ; LINES
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000295890100003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278673]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Peng, Hongli
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ding, Derong,Zhang, Baozi,Meng, Tao,et al. Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(21):7287-7291.
APA	Ding, Derong.,Zhang, Baozi.,Meng, Tao.,Ma, Ying.,Wang, Xin.,...&Shen, Jingkang.(2011).Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells.ORGANIC & BIOMOLECULAR CHEMISTRY,9(21),7287-7291.
MLA	Ding, Derong,et al."Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells".ORGANIC & BIOMOLECULAR CHEMISTRY 9.21(2011):7287-7291.