Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees

doi:10.1038/embor.2011.9

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	Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees
	Spannhoff, Astrid 1; Kim, Yong Kee 1; Raynal, Noel J. -M.2; Gharibyan, Vazganush 2; Su, Ming-Bo 3; Zhou, Yue-Yang 3; Li, Jia3 ; Castellano, Sabrina 4; Sbardella, Gianluca 4; Issa, Jean-Pierre J.2
刊名	EMBO REPORTS
	2011-03
卷号	12 期号:3 页码:238-243
关键词	Apis mellifera epigenetic HDAC inhibitor phenotypic plasticity royal jelly
ISSN号	1469-221X
DOI	10.1038/embor.2011.9
文献子类	Article
英文摘要	Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly-the secretion produced by the hypopharyngeal and mandibular glands of worker bees-has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly.
资助项目	National Institute of Environmental Health Sciences[NIEHS ES007784] ; German Research Foundation[SP 1262/1-1] ; Ministero dell'Universita e della Ricerca Scientifica e Tecnologica[00000000] ; Universita di Salerno, Italy[00000000]
WOS关键词	MEDIATED APOPTOSIS ; DNA METHYLATION ; ONCOGENIC RAS ; FATTY-ACID ; STEM-CELLS ; HONEY-BEE ; EXPRESSION ; DIFFERENTIATION ; DECITABINE ; FAS
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	WILEY
WOS记录号	WOS:000287961800016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278594]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	Bedford, Mark T.
作者单位	1.Univ Texas MD Anderson Canc Ctr, Dept Mol Carcinogenesis, Smithville, TX 78957 USA; 2.Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA; 3.Chinese Acad Sci, Shanghai Inst Mat, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 4.Univ Salerno, Epigenet Med Chem Lab, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy
推荐引用方式 GB/T 7714	Spannhoff, Astrid,Kim, Yong Kee,Raynal, Noel J. -M.,et al. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees[J]. EMBO REPORTS,2011,12(3):238-243.
APA	Spannhoff, Astrid.,Kim, Yong Kee.,Raynal, Noel J. -M..,Gharibyan, Vazganush.,Su, Ming-Bo.,...&Bedford, Mark T..(2011).Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.EMBO REPORTS,12(3),238-243.
MLA	Spannhoff, Astrid,et al."Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees".EMBO REPORTS 12.3(2011):238-243.