Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

doi:10.1021/ol200234r

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	Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product
	Carbone, Marianna 2; Li, Yan 1; Irace, Carlo 3; Mollo, Ernesto 2; Castelluccio, Francesco 2; Di Pascale, Antonio 3; Cimino, Guido 2; Santamaria, Rita 3; Guo, Yue-Wei1 ; Gavagnin, Margherita 2
刊名	ORGANIC LETTERS
	2011-05-20
卷号	13 期号:10 页码:2516-2519
ISSN号	1523-7060
DOI	10.1021/ol200234r
文献子类	Article
英文摘要	Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.
资助项目	National S & T Major Project[2009ZX09301-001] ; national marine 863 project[2007AA09Z447] ; national marine 863 project[2007AA09Z402] ; NSFC[40976048] ; NSFC[30730108] ; NSFC[20721003] ; NSFC[20772136] ; CAS[KSX2-YW-R-18] ; CAS[SIMM0907KF-09] ; PRIN-MIUR[00000000]
WOS关键词	INDOLE ALKALOIDS ; BIOISOSTERIC TRANSFORMATIONS ; CARBOXYLIC FUNCTIONALITIES ; DRUG LEADS ; OXADIAZOLES ; RECEPTOR ; POTENT ; DERIVATIVES ; DISCOVERY ; SPONGE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000290465800002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278524]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.CNR, ICB, I-80078 Pozzuoli, NA, Italy; 3.Univ Naples Federico 2, Fac Farm, Dipartimento Farmacol Sperimentale, Naples, Italy
推荐引用方式 GB/T 7714	Carbone, Marianna,Li, Yan,Irace, Carlo,et al. Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product[J]. ORGANIC LETTERS,2011,13(10):2516-2519.
APA	Carbone, Marianna.,Li, Yan.,Irace, Carlo.,Mollo, Ernesto.,Castelluccio, Francesco.,...&Gavagnin, Margherita.(2011).Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product.ORGANIC LETTERS,13(10),2516-2519.
MLA	Carbone, Marianna,et al."Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product".ORGANIC LETTERS 13.10(2011):2516-2519.