Recent Sino-Italian collaborative studies on marine organisms from the South China Sea

doi:10.1351/PAC-CON-11-09-04

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Recent Sino-Italian collaborative studies on marine organisms from the South China Sea
	Guo, Yue-Wei2 ; Gavagnin, Margherita 1; Carbone, Marianna 1; Mollo, Ernesto 1; Cimino, Guido 1
刊名	PURE AND APPLIED CHEMISTRY
	2012
卷号	84 期号:6 页码:1391-1405
关键词	bioactive molecules cnidarians marine chemistry molluscs natural products NMR organic chemistry polypropionates structures terpenoids
ISSN号	0033-4545
DOI	10.1351/PAC-CON-11-09-04
文献子类	Article
英文摘要	In this communication, selected results obtained in the course of a 10-year Sino-Italian collaborative project are presented. During this collaboration, several studies on marine organisms collected in the South China Sea have been conducted, resulting in the characterization of a large number of novel natural products. The main interest has been focused on sponges, cnidarians, and molluscs. Here, the recent research, including some not yet published studies, on cnidarians and molluscs, in particular, opisthobranchs and pulmonates, will be briefly described. The study of cnidarians and pulmonates led to isolate molecules, in particular, biscembranoids and polypropionates, displaying carbon skeletons already described in previous papers. Our studies resulted in their complete structural characterization including the absolute stereochemistry that was clarified by coupling X-ray diffraction to circular dichroism (CD) spectra analysis. Some unique nitrogenous molecules containing either an isonitrile function or an 1,2,4-oxadiazole moiety, this latter found for the first time in a marine organism, as well as known sesterterpenoids and diterpenoids were isolated from opisthobranchs. Owing to their anatomical location, these metabolites should play a relevant role in the protection of the molluscs. Finally, a series of alkaloids structurally related to known anticancer agents were also characterized.
WOS关键词	CORAL SARCOPHYTON-TORTUOSUM ; PROBABLE BIOGENETIC PRECURSOR ; GLOSSODORIS-ATROMARGINATA ; SPONGIAN DITERPENOIDS ; NATURAL-PRODUCTS ; NUDIBRANCH ; POTENT ; CEMBRANOLIDES ; CHROMODORIS ; OXADIAZOLES
WOS研究方向	Chemistry
语种	英语
出版者	INT UNION PURE APPLIED CHEMISTRY
WOS记录号	WOS:000304210400009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278259]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Cimino, Guido
作者单位	1.CNR, ICB, I-80078 Pozzuoli, NA, Italy; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yue-Wei,Gavagnin, Margherita,Carbone, Marianna,et al. Recent Sino-Italian collaborative studies on marine organisms from the South China Sea[J]. PURE AND APPLIED CHEMISTRY,2012,84(6):1391-1405.
APA	Guo, Yue-Wei,Gavagnin, Margherita,Carbone, Marianna,Mollo, Ernesto,&Cimino, Guido.(2012).Recent Sino-Italian collaborative studies on marine organisms from the South China Sea.PURE AND APPLIED CHEMISTRY,84(6),1391-1405.
MLA	Guo, Yue-Wei,et al."Recent Sino-Italian collaborative studies on marine organisms from the South China Sea".PURE AND APPLIED CHEMISTRY 84.6(2012):1391-1405.