Bicunningines A and B, Two New Dimeric Diterpenes from Cunninghamia lanceolata

doi:10.1021/ol202915r

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	Bicunningines A and B, Two New Dimeric Diterpenes from Cunninghamia lanceolata
	Hou, Xian-Feng 1,2; Yao, Sheng1,2 ; Mandi, Attila 3; Kurtan, Tibor 3; Tang, Chun-Ping1,2 ; Ke, Chang-Qiang1,2 ; Li, Xi-Qiang 1,2; Ye, Yang1,2
刊名	ORGANIC LETTERS
	2012-01-20
卷号	14 期号:2 页码:460-463
ISSN号	1523-7060
DOI	10.1021/ol202915r
文献子类	Article
英文摘要	Two unprecedented dimeric diterpenoids, with a 2,3-dihydrofuran ring fusing an abietane and a 4,5-seco-abietane diterpene, were isolated from Cunninghamia lanceolate. Their structures were elucidated by spectroscopic measurements, and their absolute configurations were determined by quantum chemical TDDFT ECD calculations, chemical transformations, and Mosher's method. The Mosher method carried out with MPA and MTPA esters of the sterically hindered sec-hydroxyl group gave contradictory results, while MPA afforded the correct absolute configuration.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National Natural Science Funds for Distinguished Young Scholar[30925043] ; Ministry of Science and Technology[2010DFA30980]
WOS关键词	ABSOLUTE-CONFIGURATION ; CRYPTOMERIA-JAPONICA ; HEARTWOOD ; ABIETANE ; LIGNANS ; ROOTS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000299238600009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278212]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, SIMM CUHK Joint Res Lab Promoting Globlizat Tradi, Shanghai 201203, Peoples R China; 3.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary
推荐引用方式 GB/T 7714	Hou, Xian-Feng,Yao, Sheng,Mandi, Attila,et al. Bicunningines A and B, Two New Dimeric Diterpenes from Cunninghamia lanceolata[J]. ORGANIC LETTERS,2012,14(2):460-463.
APA	Hou, Xian-Feng.,Yao, Sheng.,Mandi, Attila.,Kurtan, Tibor.,Tang, Chun-Ping.,...&Ye, Yang.(2012).Bicunningines A and B, Two New Dimeric Diterpenes from Cunninghamia lanceolata.ORGANIC LETTERS,14(2),460-463.
MLA	Hou, Xian-Feng,et al."Bicunningines A and B, Two New Dimeric Diterpenes from Cunninghamia lanceolata".ORGANIC LETTERS 14.2(2012):460-463.