Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

doi:10.1038/aps.2012.126

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components
	Wu, Wen-yu; Wang, Yi-ping
刊名	ACTA PHARMACOLOGICA SINICA
	2012-09
卷号	33 期号:9 页码:1119-1130
关键词	traditional Chinese medicine Salvia miltiorrhiza depside salt magnesium lithospermate B (lithospermic acid B or salvianolic acid B) rosmarinic acid lithospermic acid cardiovascular activities
ISSN号	1671-4083
DOI	10.1038/aps.2012.126
文献子类	Review
英文摘要	Salvia miltiorrhiza, a traditional medical herb known as danshen, has been widely used in China to improve blood circulation, relieve blood stasis, and treat coronary heart disease. S miltiorrhiza depside salt is a novel drug recently developed at the Shanghai Institute of Materia Medica; it contains magnesium lithospermate B (MLB) and its analogs, rosmarinic acid (RA) and lithospermic acid (LA), as active components. The drug has been used in the clinic to improve blood circulation and treat coronary heart disease. The pharmacological effects of the depside salt from S miltiorrhiza and its components have been extensively investigated. Experimental studies have demonstrated that magnesium lithospermate B possesses a variety of biological activities, especially protective effects in the cardiovascular system such as attenuation of atherosclerosis and protection against myocardial ischemia-reperfusion injury. Rosmarinic acid and lithospermic acid also show beneficial effects on the cardiovascular system. This paper reviews the recent findings regarding the mechanisms underlying the pharmacological actions of the active components of S miltiorrhiza depside salt, based on published works and our own observations.
资助项目	Shanghai Committee of Science and Technology, China[09DZ1977402] ; Ministry of Science and Technology of China[2010ZX09502-003] ; Ministry of Science and Technology of China[2003AA2Z3269]
WOS关键词	MAGNESIUM-LITHOSPERMATE-B ; SMOOTH-MUSCLE-CELLS ; HEPATIC STELLATE CELLS ; NECROSIS-FACTOR-ALPHA ; TO-MESENCHYMAL TRANSITION ; AORTIC ENDOTHELIAL-CELLS ; DEFICIENT MOUSE AORTA ; ACID-B ; ROSMARINIC ACID ; IN-VITRO
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:4635863
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000308391000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277960]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Yi-ping
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Wen-yu,Wang, Yi-ping. Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1119-1130.
APA	Wu, Wen-yu,&Wang, Yi-ping.(2012).Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components.ACTA PHARMACOLOGICA SINICA,33(9),1119-1130.
MLA	Wu, Wen-yu,et al."Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components".ACTA PHARMACOLOGICA SINICA 33.9(2012):1119-1130.