Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis

doi:10.1021/ja310482z

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	Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis
	Zhang, Bo 2; Wang, Yao 1; Yang, Shen-Ping 2; Zhou, Yu2 ; Wu, Wen-Bin 2; Tang, Wei2 ; Zuo, Jian-Ping2 ; Li, Ying 1; Yue, Jian-Min1,2
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2012-12-26
卷号	134 期号:51 页码:20605-20608
ISSN号	0002-7863
DOI	10.1021/ja310482z
文献子类	Article
英文摘要	Ivorenolide A (1), a novel 18-membered macrolide featuring conjugated acetylenic bonds and five chiral centers, was isolated from Khaya ivorensis. The structure of 1 was fully determined by spectroscopic analysis, single-crystal X-ray diffraction, and bioinspired total synthesis. Both compound 1 and its synthetic enantiomer 2 showed potent and selective immunosuppressive activity.
资助项目	National Natural Science Foundation of China[81021062] ; National Natural Science Foundation of China[20902095] ; Foundation from the MOST of China[2012CB721105]
WOS关键词	STEREOSELECTIVE TOTAL-SYNTHESIS ; ACIDS ; PALMEROLIDE ; ALDEHYDES ; MELIACEAE ; ISOMERS ; KETONES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000313154200010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277839]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室药理学第一研究室
通讯作者	Li, Ying
作者单位	1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Bo,Wang, Yao,Yang, Shen-Ping,et al. Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2012,134(51):20605-20608.
APA	Zhang, Bo.,Wang, Yao.,Yang, Shen-Ping.,Zhou, Yu.,Wu, Wen-Bin.,...&Yue, Jian-Min.(2012).Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,134(51),20605-20608.
MLA	Zhang, Bo,et al."Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134.51(2012):20605-20608.