Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault

doi:10.1016/j.bmcl.2012.12.087

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	Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault
	Liang, Lin-Fu 2; Wang, Xu-Jie 2; Zhang, Hai-Yan2 ; Liu, Hai-Li 2; Li, Jia2 ; Lan, Le-Fu2 ; Zhang, Wen 1; Guo, Yue-Wei2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2013-03-01
卷号	23 期号:5 页码:1334-1337
关键词	Soft coral Sinularia depressa Steroid Neuroprotective Antibacterial PTP1B
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2012.12.087
文献子类	Article
英文摘要	Two new steroids, (2 beta,3 beta,4 alpha,5 alpha,8 beta)-4-methylergost-24(28)-ene-2,3,8-triol (1) and (3 beta,7 alpha)-24-methyl-7-hydroperoxycholest- 5,24(28)-diene-3-ol (2), together with 13 known analogues (3-15) were isolated from the soft coral Sinularia depressa Tixier-Durivault. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. In the bioassay in vitro, compounds 3a, 4, and 14 exhibited potent PTP1B inhibitory activity, being similar as that of positive control oleanolic acid. Compound 14 also displayed a notable neuroprotective activity against both amyloid-beta(25-35)-and serum deprivation-induced injuries in SH-SY5Y cells while compound 11 showed a considerable antibacterial activity against Staphylococcus aureus. Preliminary structure-activity relationships of these steroids were discussed. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
资助项目	Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[81273430] ; National Marine '863' Project[2011AA-09070102] ; National Marine '863' Project[2013AA092902] ; SKLDR/SIMM Project[SIMM1203ZZ-03]
WOS关键词	MARINE-INVERTEBRATES ; LITOPHYTON-VIRIDIS ; METABOLITES ; NEPHTHEA
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000314693400036
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277718]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第二研究室药理学第三研究室药物安全性评价中心国家新药筛选中心
通讯作者	Zhang, Wen
作者单位	1.Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Liang, Lin-Fu,Wang, Xu-Jie,Zhang, Hai-Yan,et al. Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(5):1334-1337.
APA	Liang, Lin-Fu.,Wang, Xu-Jie.,Zhang, Hai-Yan.,Liu, Hai-Li.,Li, Jia.,...&Guo, Yue-Wei.(2013).Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(5),1334-1337.
MLA	Liang, Lin-Fu,et al."Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.5(2013):1334-1337.