Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi

doi:10.1016/j.tet.2012.12.051

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi
	Cai, You-Sheng 4; Yao, Li-Gong 4; Di Pascale, Antonio 2; Irace, Carlo 2; Mollo, Ernesto 1; Taglialatela-Scafati, Orazio 3; Guo, Yue-Wei4
刊名	TETRAHEDRON
	2013-03-04
卷号	69 期号:9 页码:2214-2219
关键词	Cladiella krempfi Diterpenoids Eunicellin Structure elucidation Bioactivity
ISSN号	0040-4020
DOI	10.1016/j.tet.2012.12.051
文献子类	Article
英文摘要	A detailed chemical investigation of the Chinese soft coral Cladiella krempfi has yielded four new eunicellin-based diterpenoids along with five known compounds. The stereostructures of the new metabolites have been elucidated by extensive spectroscopic analysis, mainly based on 2D NMR spectroscopy, and by chemical transformations. A remarkable variation in the diterpene composition in dependence of the exact site of collection was observed. Some of the isolated diterpenoids were shown to exhibit antiproliferative activity against C6 glioma cells, multi-drug resistant tumor cell line. (c) 2012 Elsevier Ltd. All rights reserved.
资助项目	Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[21021063] ; National Marine '863' Project[2011AA09070102] ; National Marine '863' Project[2013AA092902] ; SKLDR/SIMM Projects[SIMM1203ZZ-03] ; EU 7th Framework Programme-IRSES Project[00000000]
WOS关键词	SINULARIA-FLEXIBILIS ; LITOPHYTON SP ; A-D ; SCLEROPHYTIN ; OCTOCORALLIA
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000315062900018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277700]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Taglialatela-Scafati, Orazio
作者单位	1.Ist Chim Biomol ICB CNR, I-80078 Naples, Italy; 2.Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy; 3.Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China;
推荐引用方式 GB/T 7714	Cai, You-Sheng,Yao, Li-Gong,Di Pascale, Antonio,et al. Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi[J]. TETRAHEDRON,2013,69(9):2214-2219.
APA	Cai, You-Sheng.,Yao, Li-Gong.,Di Pascale, Antonio.,Irace, Carlo.,Mollo, Ernesto.,...&Guo, Yue-Wei.(2013).Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi.TETRAHEDRON,69(9),2214-2219.
MLA	Cai, You-Sheng,et al."Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi".TETRAHEDRON 69.9(2013):2214-2219.