Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones

doi:10.1021/jo400228g

	Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones
	Ji, Xun 1,2; Zhou, Yu1 ; Wang, Jinfang 1; Zhao, Linxiang 2; Jiang, Hualiang1,2 ; Liu, Hong1
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2013-05-03
卷号	78 期号:9 页码:4312-4318
ISSN号	0022-3263
DOI	10.1021/jo400228g
文献子类	Article
英文摘要	An efficient and facile Au(I)/Ag(I)-catalyzed cascade method has been developed for one-pot synthesis of the complex polycylic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives through treatment of the substituted 2-(1H-benzo[d]imidazol-2-yl)anilines with 4-pentynoic acid or 5-hexynoic acid. The strategy features a Au(I)/Ag(I)-catalyzed one-pot cascade process involving the formation of three new C-N bonds in high yields, and with broad a substrate scope.
资助项目	National Basic Research Program of China[2009CB940903] ; National Basic Research Program of China[2009CB918502] ; National Basic Research Program of China[2012CB518005] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National Natural Science Foundation of China[81102307] ; National S&T Major Projects[2012ZX09103-101-072] ; China-EU Science and Technology Cooperation Project[1109] ; Silver Project[260644]
WOS关键词	RECEPTOR TYROSINE KINASE ; DIPEPTIDYL PEPTIDASE-IV ; CONCISE TOTAL-SYNTHESIS ; GOLD CATALYSIS ; BIOLOGICAL EVALUATION ; EFFICIENT SYNTHESIS ; ANTITUMOR AGENTS ; INHIBITOR ; POTENT ; DERIVATIVES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000318588800012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277623]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Zhou, Yu
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ji, Xun,Zhou, Yu,Wang, Jinfang,et al. Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones[J]. JOURNAL OF ORGANIC CHEMISTRY,2013,78(9):4312-4318.
APA	Ji, Xun,Zhou, Yu,Wang, Jinfang,Zhao, Linxiang,Jiang, Hualiang,&Liu, Hong.(2013).Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones.JOURNAL OF ORGANIC CHEMISTRY,78(9),4312-4318.
MLA	Ji, Xun,et al."Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones".JOURNAL OF ORGANIC CHEMISTRY 78.9(2013):4312-4318.