Palladium-Catalyzed Route to Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 2,2a(1),4-Triazacyclopenta[cd]indenes

doi:10.1002/adsc.201300309

	Palladium-Catalyzed Route to Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 2,2a(1),4-Triazacyclopenta[cd]indenes
	Yang, Anjiang 1,2; Jiang, Ruwei 1; Khorev, Oleg 3; Yu, Ting 1; Zhang, Yongliang 1; Ma, Lanping1 ; Chen, Guohua 2; Shen, Jingkang 1; Meng, Tao1
刊名	ADVANCED SYNTHESIS & CATALYSIS
	2013-07-08
卷号	355 期号:10 页码:1984-1988
关键词	cyclazines cyclization multicomponent reactions nitrogen heterocycles palladium 2 2a(1) 4-triazacyclopenta[cd]indenes
ISSN号	1615-4150
DOI	10.1002/adsc.201300309
文献子类	Article
英文摘要	An efficient tandem route to the synthesis of 2,2a(1),4-triazacyclopenta[cd] indene derivatives of the cyclazine family has been developed. The target compounds were obtained in moderate to good yields by an ytterbium(III) triflate/palladium(II) acetate-catalyzed three-component domino reaction involving a palladium-catalyzed intramolecular alpha-arylation of an alpha-aminocarbonyl functionality. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the privileged imidazo[1,2-a] pyridine structure.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09103-101-026] ; National Natural Science Foundation of China[81001355] ; National Natural Science Foundation of China[81273367]
WOS关键词	INTRAMOLECULAR ALPHA-ARYLATION ; COMBINATORIAL SYNTHESIS ; RATE ACCELERATION ; KETONES ; CONDENSATION ; HETEROCYCLES ; OXINDOLES ; PYRAZINES
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000327814900014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277542]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Shen, Jingkang
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China; 3.Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
推荐引用方式 GB/T 7714	Yang, Anjiang,Jiang, Ruwei,Khorev, Oleg,et al. Palladium-Catalyzed Route to Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 2,2a(1),4-Triazacyclopenta[cd]indenes[J]. ADVANCED SYNTHESIS & CATALYSIS,2013,355(10):1984-1988.
APA	Yang, Anjiang.,Jiang, Ruwei.,Khorev, Oleg.,Yu, Ting.,Zhang, Yongliang.,...&Meng, Tao.(2013).Palladium-Catalyzed Route to Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 2,2a(1),4-Triazacyclopenta[cd]indenes.ADVANCED SYNTHESIS & CATALYSIS,355(10),1984-1988.
MLA	Yang, Anjiang,et al."Palladium-Catalyzed Route to Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 2,2a(1),4-Triazacyclopenta[cd]indenes".ADVANCED SYNTHESIS & CATALYSIS 355.10(2013):1984-1988.