InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3pyranone and Amines

doi:10.1021/ol401489x

	InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3pyranone and Amines
	Wang, Pingyuan 1,2,3; Song, Shanshan 4; Miao, Zehong 4; Yang, Guangfu 1; Zhang, Ao2,3
刊名	ORGANIC LETTERS
	2013-08-02
卷号	15 期号:15 页码:3852-3855
ISSN号	1523-7060
DOI	10.1021/ol401489x
文献子类	Article
英文摘要	An efficient one-pot synthesis of polyhydroxyalkyl-substituted pyrroles from 1,2-cyclopropa-3-pyranones with primary amines is reported. With 10% of InBr3 as the catalyst, both aryl- and alkylamines as well as various 1,2-cyclopropa-3-pyranones are well tolerated. This method is highly appealing because of its one-pot process, mild reaction conditions, substrate simplicity, and broad substrate scope.
资助项目	Distinguished Young Scholars of Chinese NSF[81125021] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program", China[2012ZX09103-101-035] ; National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001-001] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation (CAS)[00000000] ; State Key Laboratory of Drug Research[SIMM1302KF-08] ; Shanghai Institute of Materia Medica[00000000]
WOS关键词	DONOR-ACCEPTOR CYCLOPROPANES ; DIASTEREOSELECTIVE SYNTHESIS ; CYCLOADDITION REACTIONS ; RING-EXPANSION ; NITRILES ; PYRROLES ; DERIVATIVES ; CYCLIZATION ; STRATEGY ; SUGAR
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000322853000013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277512]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Yang, Guangfu
作者单位	1.Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 200031, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wang, Pingyuan,Song, Shanshan,Miao, Zehong,et al. InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3pyranone and Amines[J]. ORGANIC LETTERS,2013,15(15):3852-3855.
APA	Wang, Pingyuan,Song, Shanshan,Miao, Zehong,Yang, Guangfu,&Zhang, Ao.(2013).InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3pyranone and Amines.ORGANIC LETTERS,15(15),3852-3855.
MLA	Wang, Pingyuan,et al."InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3pyranone and Amines".ORGANIC LETTERS 15.15(2013):3852-3855.