Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance | |
Zhu, Zhiyuan; Yan, Jianming; Jiang, Wei; Yao, Xin-gang; Chen, Jing![]() ![]() ![]() ![]() | |
刊名 | JOURNAL OF NEUROSCIENCE
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2013-08-07 | |
卷号 | 33期号:32页码:13138-13149 |
ISSN号 | 0270-6474 |
DOI | 10.1523/JNEUROSCI.4790-12.2013 |
文献子类 | Article |
英文摘要 | Alzheimer's disease (AD) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. The beta-amyloid (A beta)-induced neurodegeneration is believed to be the main pathological mechanism of AD, and A beta production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-AD research. Here, we report that the natural product arctigenin from Arctium lappa (L.) can both inhibit A beta production by suppressing beta-site amyloid precursor protein cleavage enzyme 1 expression and promote A beta clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation as investigated in cells and APP/PS1 transgenic AD model mice. Moreover, the results showing that treatment of arctigenin in mice highly decreased A beta formation and senile plaques and efficiently ameliorated AD mouse memory impairment strongly highlight the potential of arctigenin in anti-AD drug discovery. |
资助项目 | State Key Program of Basic Research of China[2010CB912501] ; National Natural Science Foundation of China[81173105] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[91213306] ; National Natural Science Foundation of China[30925040] ; Shanghai Basic Research Project from the Shanghai Science and Technology Commission[11ZR1444500] ; Shanghai Basic Research Project from the Shanghai Science and Technology Commission[11XD1406100] ; China Postdoctoral Science Foundation[2012M520051] |
WOS关键词 | ACTIVATED PROTEIN-KINASE ; MOUSE MODEL ; THERAPEUTIC TARGET ; BACE1 EXPRESSION ; MAMMALIAN TARGET ; CELL-DEATH ; LIFE-SPAN ; IN-VITRO ; AUTOPHAGY ; AMPK |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | SOC NEUROSCIENCE |
WOS记录号 | WOS:000322823300023 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/277508] ![]() |
专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 药理学第三研究室 |
通讯作者 | Shen, Xu |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Zhu, Zhiyuan,Yan, Jianming,Jiang, Wei,et al. Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance[J]. JOURNAL OF NEUROSCIENCE,2013,33(32):13138-13149. |
APA | Zhu, Zhiyuan.,Yan, Jianming.,Jiang, Wei.,Yao, Xin-gang.,Chen, Jing.,...&Shen, Xu.(2013).Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance.JOURNAL OF NEUROSCIENCE,33(32),13138-13149. |
MLA | Zhu, Zhiyuan,et al."Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance".JOURNAL OF NEUROSCIENCE 33.32(2013):13138-13149. |
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