Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis

doi:10.1016/j.phytochem.2013.10.003

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	Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis
	Lai, Yongji 2; Xue, Yongbo 2; Zhang, Mengke 2; Zhang, Jinwen 3; Tang, Wei4 ; Liu, Junjun 2; Lei, Liang 2; Yan, Juming 1; Luo, Zengwei 2; Zuo, Jianping4
刊名	PHYTOCHEMISTRY
	2013-12
卷号	96 页码:378-388
关键词	Salvia scapiformis Lamiaceae Germacrane sesquiterpene Conformation Chemical transformation Quantum mechanical calculation Cytotoxicity Immunomodulatory activity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2013.10.003
文献子类	Article
英文摘要	Nine germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety, scapiformolactones A-I (1-9), and one known seco-germacrane sesquiterpenoid, 3,7,11-trimethyldodeca-1,6,9-triene-3,11-diol (10), were isolated from whole plants of Salvia scapiformis Hance. Their structures were elucidated by spectroscopic methods including HR-ESIMS, IR, UV, NMR, and CD, as well as by quantum mechanical calculations and chemical transformations. Structures of compounds 1-3 were also confirmed by single-crystal X-ray diffraction analysis. Six germacrane 6,15-diol derivatives (11-16) were obtained by chemical transformation. Compounds 1-9 and 11-16 were evaluated for their in vitro immunomodulatory effects on T and B cells, as well as their in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2013 Elsevier Ltd. All rights reserved.
资助项目	Hubei Key Laboratory Foundation of Natural Medicinal Chemistry and Resource Evaluation[00000000] ; Huazhong University of Science and Technology[2010-3] ; Fundamental Research Funds for the Central Universities[HUST: 2012QN003] ; Scientific Research Foundation for the Returned Oversea Chinese Scholars[00000000] ; State Education Ministry of China[2010-1561] ; State Education Ministry of China[40th] ; State Education Ministry of China[NCET-2008-0224] ; Program for New Century Excellent Talents in University[00000000]
WOS关键词	DIELS-F TOMENTOSA ; ROBOROWSKII ; ESTERS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000328869500040
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277349]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yao, Guangmin
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Lai, Yongji,Xue, Yongbo,Zhang, Mengke,et al. Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis[J]. PHYTOCHEMISTRY,2013,96:378-388.
APA	Lai, Yongji.,Xue, Yongbo.,Zhang, Mengke.,Zhang, Jinwen.,Tang, Wei.,...&Zhang, Yonghui.(2013).Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis.PHYTOCHEMISTRY,96,378-388.
MLA	Lai, Yongji,et al."Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis".PHYTOCHEMISTRY 96(2013):378-388.