Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia | |
Yu, Jin-Hai; Shen, Yu; Liu, Hong-Bing; Leng, Ying![]() ![]() | |
刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
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2014 | |
卷号 | 12期号:26页码:4716-4722 |
ISSN号 | 1477-0520 |
DOI | 10.1039/c4ob00807c |
文献子类 | Article |
英文摘要 | An exploration for 11 beta-HSD1 inhibitors from Homonoia riparia returned eight new dammarane-type triterpenoids, horipenoids A-H (1-8), and a known oleanane-type triterpenoid (9). Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data, and the absolute configuration of horipenoid E (5) was established by single crystal X-ray crystallography. Compounds 1-4 represent a rare class of octanortriterpenoids. Horipenoids C (3) and E (5) showed potent inhibition against mouse 11 beta-HSD1 with IC50 values of 0.810 +/- 0.058 and 0.898 +/- 0.215 mu M, respectively. |
资助项目 | National Natural Science Foundation[21272244] ; Ministry of Science and Technology of People's Republic of China[2012CB721105] |
WOS关键词 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 ; LEAVES ; CYCLOARTANE ; RESIN |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000337139800025 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/277285] ![]() |
专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 期刊编辑部 新药研究国家重点实验室 分析化学研究室 |
通讯作者 | Zhang, Hua |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Jin-Hai,Shen, Yu,Liu, Hong-Bing,et al. Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(26):4716-4722. |
APA | Yu, Jin-Hai,Shen, Yu,Liu, Hong-Bing,Leng, Ying,Zhang, Hua,&Yue, Jian-Min.(2014).Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia.ORGANIC & BIOMOLECULAR CHEMISTRY,12(26),4716-4722. |
MLA | Yu, Jin-Hai,et al."Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia".ORGANIC & BIOMOLECULAR CHEMISTRY 12.26(2014):4716-4722. |
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