Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia

doi:10.1039/c4ob00807c

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	Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia
	Yu, Jin-Hai; Shen, Yu; Liu, Hong-Bing; Leng, Ying; Zhang, Hua; Yue, Jian-Min
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2014
卷号	12 期号:26 页码:4716-4722
ISSN号	1477-0520
DOI	10.1039/c4ob00807c
文献子类	Article
英文摘要	An exploration for 11 beta-HSD1 inhibitors from Homonoia riparia returned eight new dammarane-type triterpenoids, horipenoids A-H (1-8), and a known oleanane-type triterpenoid (9). Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data, and the absolute configuration of horipenoid E (5) was established by single crystal X-ray crystallography. Compounds 1-4 represent a rare class of octanortriterpenoids. Horipenoids C (3) and E (5) showed potent inhibition against mouse 11 beta-HSD1 with IC50 values of 0.810 +/- 0.058 and 0.898 +/- 0.215 mu M, respectively.
资助项目	National Natural Science Foundation[21272244] ; Ministry of Science and Technology of People's Republic of China[2012CB721105]
WOS关键词	11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 ; LEAVES ; CYCLOARTANE ; RESIN
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000337139800025
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277285]
专题	天然药物化学研究室中科院受体结构与功能重点实验室期刊编辑部新药研究国家重点实验室分析化学研究室
通讯作者	Zhang, Hua
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yu, Jin-Hai,Shen, Yu,Liu, Hong-Bing,et al. Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(26):4716-4722.
APA	Yu, Jin-Hai,Shen, Yu,Liu, Hong-Bing,Leng, Ying,Zhang, Hua,&Yue, Jian-Min.(2014).Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia.ORGANIC & BIOMOLECULAR CHEMISTRY,12(26),4716-4722.
MLA	Yu, Jin-Hai,et al."Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia".ORGANIC & BIOMOLECULAR CHEMISTRY 12.26(2014):4716-4722.