Repair of methyl lesions in RNA by oxidative demethylation

doi:10.1039/c4md00256c

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物发现与设计中心

	Repair of methyl lesions in RNA by oxidative demethylation
	Ye, Fei 2; Zhang, Liyi 1; Jin, Lu 1; Zheng, Mingyue1 ; Jiang, Hualiang1 ; Luo, Cheng1
刊名	MEDCHEMCOMM
	2014
卷号	5 期号:12 页码:1797-1803
ISSN号	2040-2503
DOI	10.1039/c4md00256c
文献子类	Review
英文摘要	Nucleic acid methylation is one of the most important epigenetic modifications that have been studied intensively for the past several decades. Many diseases, such as cancer, neurological diseases and developmental defects, are closely associated with alkylation damage of nucleic acids. Although the majority of research on nucleic acid modification involves DNA methylation, RNA is also extensively modified. RNA methylation is a common and naturally occurring modification in both prokaryotic and eukaryotic organisms. The methylation of N6- methyladenine (m(6)A) is the most abundant modification in RNA and plays a fundamental regulatory role in gene expression. Alkylation damage in RNA can be repaired by RNA demethylases, including Escherichia coli AlkB and human AlkB homologues ALKBH1, ALKBH3, ALKBH5 and FTO. ALKBH5 and FTO are the only two m(6)A RNA demethylases identified so far. In this review, recent findings on RNA demethylases as well as biological functions and inhibitors will be discussed.
资助项目	Hi-Tech Research and Development Program of China[2012AA020302] ; National Natural Science Foundation of China[81230076] ; National Natural Science Foundation of China[81402849] ; National Natural Science Foundation of China[21210003] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09507-004] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09507001] ; Zhejiang Province Natural Science Foundation[LQ14H300003] ; Zhejiang Provincial Top Key Discipline of Biology[00000000]
WOS关键词	OBESITY-ASSOCIATED FTO ; MESSENGER-RNA ; MAMMALIAN RNA ; ALKYLATION DAMAGE ; CRYSTAL-STRUCTURE ; ESCHERICHIA-COLI ; OLD MODIFICATION ; DNA-DAMAGE ; FAT MASS ; GENE
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000345455600003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277256]
专题	药物发现与设计中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Luo, Cheng
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Zhejiang Sci Tech Univ, Coll Life Sci, Hangzhou, Zhejiang, Peoples R China;
推荐引用方式 GB/T 7714	Ye, Fei,Zhang, Liyi,Jin, Lu,et al. Repair of methyl lesions in RNA by oxidative demethylation[J]. MEDCHEMCOMM,2014,5(12):1797-1803.
APA	Ye, Fei,Zhang, Liyi,Jin, Lu,Zheng, Mingyue,Jiang, Hualiang,&Luo, Cheng.(2014).Repair of methyl lesions in RNA by oxidative demethylation.MEDCHEMCOMM,5(12),1797-1803.
MLA	Ye, Fei,et al."Repair of methyl lesions in RNA by oxidative demethylation".MEDCHEMCOMM 5.12(2014):1797-1803.