Rapid access to alpha-carbolines via a one-pot tandem reaction of alpha,beta-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products

doi:10.1039/c3ob41921e

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Rapid access to alpha-carbolines via a one-pot tandem reaction of alpha,beta-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products
	Zhang, Xiaofei; He, Qian; Xiang, Haoyue; Song, Shanshan; Miao, Zehong; Yang, Chunhao
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2014-01-14
卷号	12 期号:2 页码:355-361
ISSN号	1477-0520
DOI	10.1039/c3ob41921e
文献子类	Article
英文摘要	An effective and convenient method has been developed for the preparation of 2 or 2,4-substituted alpha-carbolines via a one-pot tandem reaction of alpha,beta-unsaturated ketones with 2-nitrophenylacetonitrile in the presence of zinc dust, acetic acid and triethylamine. This protocol presents a simple, rapid and pot/step economical strategy for preparing biologically interesting alpha-carbolines with moderate antitumor activities.
资助项目	Chinese Academy of Sciences[00000000] ; National Natural Science Foundation of China[21072205] ; National Natural Science Foundation of China[81025020] ; [SIMM1203ZZ-0103]
WOS关键词	TOPOISOMERASE-II INHIBITORS ; EFFICIENT APPROACH ; ANTITUMOR AGENTS ; DERIVATIVES ; DESIGN
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000329551700017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277230]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室
通讯作者	Miao, Zehong
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiaofei,He, Qian,Xiang, Haoyue,et al. Rapid access to alpha-carbolines via a one-pot tandem reaction of alpha,beta-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(2):355-361.
APA	Zhang, Xiaofei,He, Qian,Xiang, Haoyue,Song, Shanshan,Miao, Zehong,&Yang, Chunhao.(2014).Rapid access to alpha-carbolines via a one-pot tandem reaction of alpha,beta-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products.ORGANIC & BIOMOLECULAR CHEMISTRY,12(2),355-361.
MLA	Zhang, Xiaofei,et al."Rapid access to alpha-carbolines via a one-pot tandem reaction of alpha,beta-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products".ORGANIC & BIOMOLECULAR CHEMISTRY 12.2(2014):355-361.