Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients

doi:10.1371/journal.pone.0087904

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients
	Zhu, Jiang 1,2; Wu, Yu-Nong 1; Zhang, Wei 1; Zhang, Xiao-Min 1; Ding, Xu 1; Li, Huai-Qi 1; Geng, Meiyu3 ; Xie, Zuo-Quan3 ; Wu, He-Ming 1,2
刊名	PLOS ONE
	2014-01-30
卷号	9 期号:1
ISSN号	1932-6203
DOI	10.1371/journal.pone.0087904
文献子类	Article
英文摘要	Monocarboxylate transporter 4 (MCT4) is a cell membrane transporter of lactate. Recent studies have shown that MCT4 is over-expressed in various cancers; however, its role in cancer maintenance and aggressiveness has not been fully demonstrated. This study investigated the role of MCT4 in oral squamous cell carcinoma (OSCC), and found that it is highly expressed in OSCC patients by using immunohistochemistry. Moreover, this over-expression of MCT4 was closely associated with tumor size, TNM classification, lymphatic metastasis, distant metastasis and tumor recurrence, and also poor prognosis. To further study mechanisms of MCT4 in vitro, we used small-interfering RNA to silence its expression in OSCC cell lines. The results showed that knock-down of MCT4 decreased cell proliferation, migration, and invasion. The inhibition of proliferation was associated with down-regulation of p-AKT and p-ERK1/2, while decreased cell migration and invasion may be caused by down-regulation of integrin beta 4-SRC-FAK and MEK-ERK signaling. Together, these findings provide new insight into the critical role of MCT4 in cell proliferation and metastasis in OSCC.
资助项目	National Natural Science Foundation of China[81202549] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2012ZX09301001-007] ; Priority Academic Program Development of Jiangsu Higher Education Institutions[jx10531801/005]
WOS关键词	FOCAL-ADHESION KINASE ; SIGNALING PATHWAYS ; CANCER CELLS ; E-CADHERIN ; TYROSINE PHOSPHORYLATION ; LACTATE ; HEAD ; SRC ; MCT4 ; FAK
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000330617100120
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277218]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xie, Zuo-Quan
作者单位	1.Stomatol Hosp Jiangsu Prov, Dept Oral & Maxillofacial Surg, Nanjing, Jiangsu, Peoples R China; 2.Nanjing Med Univ, Inst Stomatol, Nanjing, Jiangsu, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Jiang,Wu, Yu-Nong,Zhang, Wei,et al. Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients[J]. PLOS ONE,2014,9(1).
APA	Zhu, Jiang.,Wu, Yu-Nong.,Zhang, Wei.,Zhang, Xiao-Min.,Ding, Xu.,...&Wu, He-Ming.(2014).Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients.PLOS ONE,9(1).
MLA	Zhu, Jiang,et al."Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients".PLOS ONE 9.1(2014).