Concise Syntheses of 1,3-Dihydroxylxanthones and Their Clearance Effections against Nitrite

doi:10.6023/cjoc201310010

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	Concise Syntheses of 1,3-Dihydroxylxanthones and Their Clearance Effections against Nitrite
	Mao Shuangshuang 2; Zheng Huanhuan 2; Luo Cuiting 2; Chen Heru 1,2,3
刊名	CHINESE JOURNAL OF ORGANIC CHEMISTRY
	2014-03
卷号	34 期号:3 页码:515-521
关键词	xanthones organic synthesis nitrite cancer prevention Eaton's reagent
ISSN号	0253-2786
DOI	10.6023/cjoc201310010
文献子类	Article
英文摘要	Twelve 1,3-dihydroxylxanthones (3a similar to 31) were synthesized under the catalysis of Eaton's reagent applying phloroglucinol and substituted salicylic acids as starting materials. The yields were from 63% to 87%. The reaction mechanism and their structure-reaction activity relationship have been discussed. The clearance effections of all the prepared xanthones against nitrite have been investigated by UV spectrophotometry. It is disclosed that all the tested xanthones have obvious clearance effections against nitrite at the conditions of pH 3, room temperature, and 30 min treatment. 3b and 31 are identified as the most active compounds with clearance rate up to 34.0%. The clearance mechanism of xanthones against nitrite and their structure-activity relationships were also included here.
资助项目	National Natural Science Foundation of China[81172982] ; Guangdong Provincial Project of Science and Technology[2010A030100006] ; State Key Laboratory of Drug Research[SIMM1302KF-12]
WOS关键词	MANGIFERA-INDICA L. ; ANTI-AIDS AGENTS ; XANTHONE DERIVATIVES ; DCX DERIVATIVES ; INHIBITORS ; DESIGN ; HIV
WOS研究方向	Chemistry
语种	中文
出版者	SCIENCE PRESS
WOS记录号	WOS:000335628500008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277163]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Mao Shuangshuang
作者单位	1.Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China 2.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Mao Shuangshuang,Zheng Huanhuan,Luo Cuiting,et al. Concise Syntheses of 1,3-Dihydroxylxanthones and Their Clearance Effections against Nitrite[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2014,34(3):515-521.
APA	Mao Shuangshuang,Zheng Huanhuan,Luo Cuiting,&Chen Heru.(2014).Concise Syntheses of 1,3-Dihydroxylxanthones and Their Clearance Effections against Nitrite.CHINESE JOURNAL OF ORGANIC CHEMISTRY,34(3),515-521.
MLA	Mao Shuangshuang,et al."Concise Syntheses of 1,3-Dihydroxylxanthones and Their Clearance Effections against Nitrite".CHINESE JOURNAL OF ORGANIC CHEMISTRY 34.3(2014):515-521.