Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities

doi:10.1021/np500042c

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	Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities
	Liu, Cui-Ping; Xu, Jin-Biao; Zhao, Jin-Xin; Xu, Cheng-Hui; Dong, Lei; Ding, Jian; Yue, Jian-Min
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-04
卷号	77 期号:4 页码:1013-1020
ISSN号	0163-3864
DOI	10.1021/np500042c
文献子类	Article
英文摘要	Fourteen new diterpenoids including clerodane (1-12), labdane (13), and norlabdane (14) types, as well as nine known analogues were isolated from the aerial parts of Croton laui. Their structures were established on the basis of spectroscopic analysis, and that of crotonolide H (11) was confirmed by single-crystal X-ray crystallography. Crotonolide A (1) exhibited moderate cytotoxicity against two tumor cell lines, HL-60 (human premyelocytic leukemia, IC50 9.42 mu M) and P-388 (murine leukemia, IC50 7.45 mu M), and crotonolide G (10) displayed significant antibacterial activity against a panel of Gram-positive bacteria.
资助项目	National Natural Science Foundation of the People's Republic of China[U1302222]
WOS关键词	OCCURRING TERPENE DERIVATIVES ; CHEMICAL-CONSTITUENTS ; TONKINENSIS ; PLANTS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000335127200038
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277130]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yue, Jian-Min
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Cui-Ping,Xu, Jin-Biao,Zhao, Jin-Xin,et al. Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):1013-1020.
APA	Liu, Cui-Ping.,Xu, Jin-Biao.,Zhao, Jin-Xin.,Xu, Cheng-Hui.,Dong, Lei.,...&Yue, Jian-Min.(2014).Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities.JOURNAL OF NATURAL PRODUCTS,77(4),1013-1020.
MLA	Liu, Cui-Ping,et al."Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities".JOURNAL OF NATURAL PRODUCTS 77.4(2014):1013-1020.