Diterpenoids from the Flowers of Rhododendron molle

doi:10.1021/np500074q

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Diterpenoids from the Flowers of Rhododendron molle
	Zhou, Shuai-Zhen 1,2,3,4; Yao, Sheng1,2,3,4 ; Tang, Chunping1,2,3,4 ; Ke, Changqiang1,2,3,4 ; Li, Lu 1,2,3,4; Lin, Ge 3,4,5; Ye, Yang1,2,3,4,6
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-05
卷号	77 期号:5 页码:1185-1192
ISSN号	0163-3864
DOI	10.1021/np500074q
文献子类	Article
英文摘要	A new seco-kalmane-type diterpenoid, seco-rhodomollone (1), five new grayanane-type diterpenoids, rhodomollein XXI (2), 6-O-acetylrhodomollein XXI (3), 6,14-di-O-acetylrhodomollein XXI (4), rhodomollein XXII (5), and 2-O-methylrhodomollein XI (6), and two new kalmane-type diterpenoids, rhodomolleins XXIII (7) and XXIV (8), together with seven known compounds, were isolated from the flowers of Rhododendron molle collected in Guangxi Province, China. The absolute configurations of 1 and 3 were defined by single-crystal X-ray diffraction experiments. Compound I possesses an unprecedented 1,5-seco-kalmane skeleton presumably derived by cleavage of the C-1-C-5 bond of the kalmane skeleton. Compounds 2-4 represent the first examples from a natural source of grayanane-type diterpenoids with a chlorine substituent.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Natural Science Funds[81302657]
WOS关键词	LEUCOTHOE-GRAYANA ; STEREOSTRUCTURE ; SKELETON ; FRUITS ; TOXINS ; ROOTS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000336510700014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277090]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ye, Yang
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Joint Res Lab Promoting Globalizat Tradit Chinese, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Shuai-Zhen,Yao, Sheng,Tang, Chunping,et al. Diterpenoids from the Flowers of Rhododendron molle[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(5):1185-1192.
APA	Zhou, Shuai-Zhen.,Yao, Sheng.,Tang, Chunping.,Ke, Changqiang.,Li, Lu.,...&Ye, Yang.(2014).Diterpenoids from the Flowers of Rhododendron molle.JOURNAL OF NATURAL PRODUCTS,77(5),1185-1192.
MLA	Zhou, Shuai-Zhen,et al."Diterpenoids from the Flowers of Rhododendron molle".JOURNAL OF NATURAL PRODUCTS 77.5(2014):1185-1192.