Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum

doi:10.1021/ja503995b

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum
	Xu, Jin-Biao 1; Zhang, Hua 1; Gan, Li-She 2; Han, Ying-Shan 3; Wainberg, Mark A.3; Yue, Jian-Min1
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2014-05-28
卷号	136 期号:21 页码:7631-7633
ISSN号	0002-7863
DOI	10.1021/ja503995b
文献子类	Article
英文摘要	Logeracemin A (1), the first Daphniphyllum alkaloid dimer featuring an unprecedented carbon skeleton with a unique conjugated trispiro[4,5] decane backbone, was isolated from Daphniphyllum longeracemosum. Its structure and absolute configuration were established on the basis of spectroscopic data and X-ray crystallography. Logeracemin A showed significant anti-HIV activity with an EC50 of 4.5 +/- 0.1 mu M and a selectivity index of 6.2. The structure-activity relationship of the tested compounds was briefly discussed.
资助项目	National Natural Science Foundation[U1302222] ; National Natural Science Foundation[81273398] ; National Natural Science Foundation[81321092] ; Foundation from the MOST of the P. R. China[2012CB721105]
WOS关键词	TETRACYCLIC CORE ; TRICYCLIC CORE ; RING-SYSTEM ; CONSTRUCTION ; CALYCIPHYLLINE ; DISCOVERY ; AGENTS ; DAPHNICYCLIDIN ; TRITERPENOIDS ; DAPHENYLLINE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000336635400027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277067]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yue, Jian-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Zhejiang Univ, Inst Modern Chinese Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 3.McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Aids Ctr, Montreal, PQ H3T 1E2, Canada
推荐引用方式 GB/T 7714	Xu, Jin-Biao,Zhang, Hua,Gan, Li-She,et al. Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(21):7631-7633.
APA	Xu, Jin-Biao,Zhang, Hua,Gan, Li-She,Han, Ying-Shan,Wainberg, Mark A.,&Yue, Jian-Min.(2014).Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(21),7631-7633.
MLA	Xu, Jin-Biao,et al."Logeracemin A, an Anti-HIV Daphniphyllum Alkaloid Dimer with a New Carbon Skeleton from Daphniphyllum longeracemosum".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.21(2014):7631-7633.