Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity

doi:10.1021/np5002237

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	Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity
	Qi, Wei-Yan 1; Zhang, Wei-Yi 1; Shen, Yu 2; Leng, Ying2 ; Gao, Kun 1; Yue, Jian-Min1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-06
卷号	77 期号:6 页码:1452-1458
ISSN号	0163-3864
DOI	10.1021/np5002237
文献子类	Article
英文摘要	Eighteen new ingol-type diterpenes, euphorantins A-R (1-18), along with four known analogues (19-22), were isolated from the aerial parts of Euphorbia antiquorum. Compounds 1-3 are the first examples of C-17-oxygenated ingol-type diterpenes, and compounds 16-18 represent a rare class of 2,3-di-epimers of ingols. Diterpenes 1, 14, and 22 exhibited inhibitory activities against mouse 11 beta-HSD1 with IC50 values of 12.0, 6.4, and 0.41 mu M, respectively.
资助项目	National Natural Science Foundation of China[31270396] ; 111 Project of China[00000000]
WOS关键词	LATEX ; ACID ; ESTERS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000340222700029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277038]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Gao, Kun
作者单位	1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Qi, Wei-Yan,Zhang, Wei-Yi,Shen, Yu,et al. Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(6):1452-1458.
APA	Qi, Wei-Yan,Zhang, Wei-Yi,Shen, Yu,Leng, Ying,Gao, Kun,&Yue, Jian-Min.(2014).Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity.JOURNAL OF NATURAL PRODUCTS,77(6),1452-1458.
MLA	Qi, Wei-Yan,et al."Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity".JOURNAL OF NATURAL PRODUCTS 77.6(2014):1452-1458.