Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus

doi:10.1021/np500379f

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	Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus
	Wang, Hongmin 1; Ning, Ruonan 1; Shen, Yu 2; Chen, Zhenhua 1; Li, Jinlong 1; Zhang, Rujun 1; Leng, Ying2 ; Zhao, Weimin1
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-08
卷号	77 期号:8 页码:1910-1920
ISSN号	0163-3864
DOI	10.1021/np500379f
文献子类	Article
英文摘要	Fourteen new 3,4-seco-cycloartane-type triterpenes, lithocarpic acids A-N (1-14), together with one known compound, coccinetane E (15), were identified from the cupules of Lithocarpus polystachyus. The structures of 1-14 were determined by spectroscopic data analysis and chemical methods, and the absolute configurations of 1 and 4 were defined unequivocally by X-ray crystallography using Cu K alpha radiation. Compounds 1-15 are the first examples of 3,4-seco-cycloartane derivatives isolated from the genus Lithocarpus. Among them, compounds 1 and 2, 9 and 10, and 11 and 12 were found to be three pairs of C-24 epimers, while compounds 7 and 8 represent the first examples of 3,4-seco-norcycloartane-type triterpenes. Compound 1, as the major component of the plant extract, showed potent antibacterial activity against Micrococcus luteus and Bacillus subtilis, with MIC values of 3.1 and 6.3 mu g/mL, respectively, as well as inhibitory activity against human and mouse 11 beta-hydroxysteroid dehydrogenase type 1, with IC50 values of 1.9 and 0.24 mu M, respectively.
资助项目	Forestry Industry Research Special Fund for Public Welfare Project[201204612]
WOS关键词	HONG-KONG ; TRITERPENOIDS ; RATS ; LEAVES ; IDENTIFICATION ; 11-BETA-HSD1 ; PHLORHIZIN ; INHIBITORS ; EXTRACT ; REHD.
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000340861800020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276956]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Leng, Ying
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hongmin,Ning, Ruonan,Shen, Yu,et al. Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1910-1920.
APA	Wang, Hongmin.,Ning, Ruonan.,Shen, Yu.,Chen, Zhenhua.,Li, Jinlong.,...&Zhao, Weimin.(2014).Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus.JOURNAL OF NATURAL PRODUCTS,77(8),1910-1920.
MLA	Wang, Hongmin,et al."Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1910-1920.