One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe

doi:10.1021/am505435s

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	One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe
	Li, Kai-Bin 1,2; Wang, Huan 1,2,3; Zang, Yi3 ; He, Xiao-Peng 1,2; Li, Jia3 ; Chen, Guo-Rong 1,2; Tian, He 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2014-11-26
卷号	6 期号:22 页码:19600-19605
关键词	click chemistry rhodamine probe triazole PEG cell imaging
ISSN号	1944-8244
DOI	10.1021/am505435s
文献子类	Article
英文摘要	This study describes the exploitation of click chemistry in the one-step molecular engineering of an unqualified rhodamine probe, leading to its considerable functional enhancement in terms of water solubility, ion selectivity, and usefulness in detecting biological and environmental samples. A dipropargyl rhodamine dye previously identified as an unselective and poorly water-soluble mercury(II) probe was used to couple with an azido polyethylene glycol (PEG) by the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition click reaction in almost quantitative yield. The simple click-engineered rhodamine probe shows, remarkably, better water solubility and mercury(II) selectivity comparing to the raw counterpart, and can be used to sensitively image mercury ions internalized by live cells and to accurately quantify the ion spiked in river water specimens. This study provides insights into the simple functional improvement of unqualified molecular dye probes via the efficient "click engineering".
资助项目	973 project[2013CB733700] ; National Science Fund for Distinguished Young Scholars[81125023] ; National Natural Science Foundation of China[21176076] ; National Natural Science Foundation of China[21202045] ; National Natural Science Foundation of China[91213303] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA01040303] ; Program of Shanghai Subject Chief Scientist[13XD1404300] ; Shanghai Science and Technology Commission[13NM1400900] ; Fundamental Research Funds for the Central Universities[00000000]
WOS关键词	GRAPHENE OXIDE ; OFF-ON ; FLUORESCENT CHEMODOSIMETER ; TERMINAL ALKYNES ; AQUEOUS-SOLUTION ; ENERGY-TRANSFER ; FLUORIDE IONS ; LIVING CELLS ; HG2+ ; HG(II)
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000345721400021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276826]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	He, Xiao-Peng
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Kai-Bin,Wang, Huan,Zang, Yi,et al. One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(22):19600-19605.
APA	Li, Kai-Bin.,Wang, Huan.,Zang, Yi.,He, Xiao-Peng.,Li, Jia.,...&Tian, He.(2014).One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe.ACS APPLIED MATERIALS & INTERFACES,6(22),19600-19605.
MLA	Li, Kai-Bin,et al."One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe".ACS APPLIED MATERIALS & INTERFACES 6.22(2014):19600-19605.