Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors

doi:10.1039/c5ra06452j

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	Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors
	Ji, Shuai 1; Qiao, Xue 1; Li, Zi-wei 1; Wang, Yong-rui 1; Yu, Si-wang 1; Liang, Wen-fei 1; Lin, Xiong-hao 1; Ye, Min 1,2
刊名	RSC ADVANCES
	2015
卷号	5 期号:56 页码:45258-45265
ISSN号	2046-2069
DOI	10.1039/c5ra06452j
文献子类	Article
英文摘要	Glycyfuranocoumarin A-C (1-3), three 3-arylcoumarins, and glycyfuranocoumarone A (4), one 2-arylcoumarone, were isolated in the racemic form from the roots of Glycyrrhiza uralensis. Their structures were elucidated by NMR, 2D NMR and HRESIMS data analyses. All the structures contain a 2,3-dihydro-2,3,3-trimethylbenzofuran ring. Chiral HPLC was used to obtain the optically pure enantiomers, (2 '' R)-1 and (2 '' S)-1. Their absolute configurations were determined by X-ray crystallography. This is the first unambiguous determination of the absolute configuration of 2,3-dihydro-2,3,3-trimethylbenzofurans. (2 '' R)-1 and (2 '' S)-1, as well as 2-4, exhibited significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Among them, 4 showed an IC50 of 2.2 mu M.
资助项目	National Natural Science Foundation of China[81173644] ; National Natural Science Foundation of China[81222054] ; Program for New Century Excellent Talents in University from Chinese Ministry of Education[NCET-11-0019] ; State Key Laboratory of Drug Research[00000000]
WOS关键词	ABSOLUTE-CONFIGURATION ; DERIVATIVES ; FLAVONOIDS ; COUMARINS ; CONSTITUENTS ; LICORICE ; DISCOVERY ; OBESITY ; ACID
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000354965300062
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276730]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ye, Min
作者单位	1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ji, Shuai,Qiao, Xue,Li, Zi-wei,et al. Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors[J]. RSC ADVANCES,2015,5(56):45258-45265.
APA	Ji, Shuai.,Qiao, Xue.,Li, Zi-wei.,Wang, Yong-rui.,Yu, Si-wang.,...&Ye, Min.(2015).Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors.RSC ADVANCES,5(56),45258-45265.
MLA	Ji, Shuai,et al."Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors".RSC ADVANCES 5.56(2015):45258-45265.