Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors | |
Ji, Shuai1; Qiao, Xue1; Li, Zi-wei1; Wang, Yong-rui1; Yu, Si-wang1; Liang, Wen-fei1; Lin, Xiong-hao1; Ye, Min1,2 | |
刊名 | RSC ADVANCES
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2015 | |
卷号 | 5期号:56页码:45258-45265 |
ISSN号 | 2046-2069 |
DOI | 10.1039/c5ra06452j |
文献子类 | Article |
英文摘要 | Glycyfuranocoumarin A-C (1-3), three 3-arylcoumarins, and glycyfuranocoumarone A (4), one 2-arylcoumarone, were isolated in the racemic form from the roots of Glycyrrhiza uralensis. Their structures were elucidated by NMR, 2D NMR and HRESIMS data analyses. All the structures contain a 2,3-dihydro-2,3,3-trimethylbenzofuran ring. Chiral HPLC was used to obtain the optically pure enantiomers, (2 '' R)-1 and (2 '' S)-1. Their absolute configurations were determined by X-ray crystallography. This is the first unambiguous determination of the absolute configuration of 2,3-dihydro-2,3,3-trimethylbenzofurans. (2 '' R)-1 and (2 '' S)-1, as well as 2-4, exhibited significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B). Among them, 4 showed an IC50 of 2.2 mu M. |
资助项目 | National Natural Science Foundation of China[81173644] ; National Natural Science Foundation of China[81222054] ; Program for New Century Excellent Talents in University from Chinese Ministry of Education[NCET-11-0019] ; State Key Laboratory of Drug Research[00000000] |
WOS关键词 | ABSOLUTE-CONFIGURATION ; DERIVATIVES ; FLAVONOIDS ; COUMARINS ; CONSTITUENTS ; LICORICE ; DISCOVERY ; OBESITY ; ACID |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000354965300062 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/276730] ![]() |
专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
通讯作者 | Ye, Min |
作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Ji, Shuai,Qiao, Xue,Li, Zi-wei,et al. Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors[J]. RSC ADVANCES,2015,5(56):45258-45265. |
APA | Ji, Shuai.,Qiao, Xue.,Li, Zi-wei.,Wang, Yong-rui.,Yu, Si-wang.,...&Ye, Min.(2015).Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors.RSC ADVANCES,5(56),45258-45265. |
MLA | Ji, Shuai,et al."Enantiomeric 3-arylcoumarins and 2-arylcoumarones from the roots of Glycyrrhiza uralensis as protein tyrosine phosphatase 1B (PTP1B) inhibitors".RSC ADVANCES 5.56(2015):45258-45265. |
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