Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

doi:10.1016/j.apsb.2014.11.001

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	Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94
	Zhou, Zhenfang 1; Wang, Xin1 ; Zhang, Hui 2; Sun, Jingya 1; Zheng, Linghui 2; Liu, Hongchun1 ; Wang, Jidong 2; Shen, Aijun1 ; Geng, Meiyu1 ; Guo, Yuewei1
刊名	ACTA PHARMACEUTICA SINICA B
	2015-01
卷号	5 期号:1 页码:62-66
关键词	Chromopeptide A Bacterium Depsipeptide Absolute configuration Marine derived Sediments Cytotoxicity Chromobacterium sp.
ISSN号	2211-3835
DOI	10.1016/j.apsb.2014.11.001
文献子类	Article
英文摘要	A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K-alpha radiation (lambda=0.71073 angstrom) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60. K-562, and Ramos cells with average IC50 values of 7,7, 7.0, and 16,5 nmol/L, respectively. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.
资助项目	National Marine '863' Project[20112AA092105] ; National Marine '863' Project[20113AA092902] ; National Natural Science Foundation of China[81273430]
WOS关键词	FR901228 ; FK228
WOS研究方向	Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5392968
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000360008000008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276715]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室药理学第一研究室分子影像中心（筹）
通讯作者	Wang, Jidong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Zhejiang Hisun Pharmaceut Co Ltd, Thizhou 318000, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Zhenfang,Wang, Xin,Zhang, Hui,et al. Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94[J]. ACTA PHARMACEUTICA SINICA B,2015,5(1):62-66.
APA	Zhou, Zhenfang.,Wang, Xin.,Zhang, Hui.,Sun, Jingya.,Zheng, Linghui.,...&Guo, Yuewei.(2015).Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94.ACTA PHARMACEUTICA SINICA B,5(1),62-66.
MLA	Zhou, Zhenfang,et al."Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94".ACTA PHARMACEUTICA SINICA B 5.1(2015):62-66.