Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives

doi:10.1039/c5ob01642h

	Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives
	Jiang, Min 1; Xiang, Haoyue 2; Zhu, Fangxia 1; Xu, Xing 1; Deng, Lianfu 1; Yang, Chunhao2
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2015
卷号	13 期号:40 页码:10122-10126
ISSN号	1477-0520
DOI	10.1039/c5ob01642h
文献子类	Article
英文摘要	An efficient and practical one-pot domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives from readily available 2-(2-bromophenyl)acetonitriles was developed. The overall protocol involves a Buchwald-Hartwig type coupling and a base-promoted intramolecular nucleophilic reaction. The reaction scope, advantages and limitations are discussed.
资助项目	Shanghai Municipal Health Bureau young scientific research project[20144Y0055] ; Shanghai Committee of Science and Technology, China[14ZR1437500] ; Shanghai Committee of Science and Technology, China[13431900702] ; NSFC[81502902] ; NSFC[81321092] ; SKLDR/SIMM[SIMM1403ZZ-01]
WOS关键词	ONE-POT SYNTHESIS ; ACCESS ; INDOLE ; ALPHA ; INDOLMYCIN ; INHIBITORS ; CHEMISTRY ; ARYLATION ; DIVERSE ; ANALOGS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000362729600005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276702]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Deng, Lianfu
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed,Shanghai Key, Shanghai 200025, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Min,Xiang, Haoyue,Zhu, Fangxia,et al. Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(40):10122-10126.
APA	Jiang, Min,Xiang, Haoyue,Zhu, Fangxia,Xu, Xing,Deng, Lianfu,&Yang, Chunhao.(2015).Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,13(40),10122-10126.
MLA	Jiang, Min,et al."Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 13.40(2015):10122-10126.