Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite

doi:10.1039/c5tb02057c

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 国家新药筛选中心

	Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite
	Ji, Ding-Kun 1,2; Zhang, Yue 1,2,3; Zang, Yi3 ; Liu, Wang 4; Zhang, Xiongwen 4; Li, Jia3 ; Chen, Guo-Rong 1,2; James, Tony D.5; He, Xiao-Peng 1,2
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2015
卷号	3 期号:47 页码:9182-9185
ISSN号	2050-750X
DOI	10.1039/c5tb02057c
文献子类	Article
英文摘要	Intercellular glycoligand-receptor interactions are implicated in a number of disease-related processes. Effective tools that target these receptors may facilitate disease theranostics. However, owing to their low binding affinity, multivalent presentation of glycoligands is needed to increase the avidity with transmembrane receptors. While previous strategies focus on the covalent coupling of glycoligands to a synthetic backbone, we show here that the use of graphene oxide (GO) greatly enhances the cellular and tissue imaging ability of a small-molecule fluorescence glycoprobe. We determine that GO with an optimum size may serve as a clustering platform to reinforce the interaction of the glycoprobe with its selective receptor on a cancer cell. This phenomenon has been consistently observed with the xenograft tissue of a tumor-bearing mouse. Using this principle we have further constructed a supramolecular glycocomposite by co-assembling the glycoprobe and an anticancer drug onto a single GO surface. In addition to imaging ability, this material displays improved toxicity for liver cancer cells that over express the glycoprotein receptor, when compared to the control cells.
资助项目	973 project[2013CB733700] ; Fundamental Research Funds for Central Universities[222201414010] ; Key Project of Shanghai Science and Technology Commission[13NM1400900] ; National Science Foundation of China[21572058] ; National Science Foundation of China[21576088] ; National Science Foundation of China[91213303]
WOS关键词	RECOGNITIONS ; COMPOSITE ; PLATFORM ; GLYCOBIOLOGY ; DISACCHARIDE ; BLEOMYCIN ; LIGANDS ; DISEASE ; LECTIN ; CELLS
WOS研究方向	Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000365532000012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276686]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zang, Yi
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 4.E China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Inst Drug Discovery & Dev, Shanghai 200062, Peoples R China; 5.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
推荐引用方式 GB/T 7714	Ji, Ding-Kun,Zhang, Yue,Zang, Yi,et al. Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(47):9182-9185.
APA	Ji, Ding-Kun.,Zhang, Yue.,Zang, Yi.,Liu, Wang.,Zhang, Xiongwen.,...&He, Xiao-Peng.(2015).Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite.JOURNAL OF MATERIALS CHEMISTRY B,3(47),9182-9185.
MLA	Ji, Ding-Kun,et al."Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite".JOURNAL OF MATERIALS CHEMISTRY B 3.47(2015):9182-9185.