Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense

doi:10.1021/np500896n

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	Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense
	Chen, Xuan-Qin 1; Shao, Li-Dong 1; Pal, Mahesh 2; Shen, Yu 3; Cheng, Xiao 1; Xu, Gang 1; Peng, Li-Yan 1; Wang, Kou 1; Pan, Zheng-Hong 1; Li, Ming-Ming 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2015-02
卷号	78 期号:2 页码:330-334
ISSN号	0163-3864
DOI	10.1021/np500896n
文献子类	Article
英文摘要	Five selective 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) competitive inhibitors, hupehenols AE (1-5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1-5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols AE (1-5) showed inhibition against human 11 beta-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11 beta-HSD1 when compared to murine 11 beta-HSD1.T
资助项目	National Natural Science Foundation of China[81102347] ; National Basic Research Program of China (973 Program)[2011CB915503]
WOS关键词	NOR-DAMMARANE TRITERPENOIDS ; METABOLIC SYNDROME ; DYSOXYLUM-HAINANENSE ; OBESITY ; DISCOVERY ; HYPERTENSION ; DITERPENOIDS ; CYLINDRICUM ; DERIVATIVES ; ACTIVATION
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000350328600024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276650]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	He, Juan
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China; 2.CSIR Natl Bot Res Inst, Phytochem Div, Lucknow 226001, Uttar Pradesh, India; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xuan-Qin,Shao, Li-Dong,Pal, Mahesh,et al. Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(2):330-334.
APA	Chen, Xuan-Qin.,Shao, Li-Dong.,Pal, Mahesh.,Shen, Yu.,Cheng, Xiao.,...&Zhao, Qin-Shi.(2015).Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense.JOURNAL OF NATURAL PRODUCTS,78(2),330-334.
MLA	Chen, Xuan-Qin,et al."Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense".JOURNAL OF NATURAL PRODUCTS 78.2(2015):330-334.