Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii

doi:10.1021/acs.joc.5b01658

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	Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii
	Xiong, Juan 3; Hong, Zhi-Lai 3; Gao, Li-Xin 2; Shen, Jie 1; Liu, Shu-Ting 3; Yang, Guo-Xun 3; Li, Jia2 ; Zeng, Huaqiang 1; Hu, Jin-Feng 3
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2015-11-06
卷号	80 期号:21 页码:11080-11085
ISSN号	0022-3263
DOI	10.1021/acs.joc.5b01658
文献子类	Article
英文摘要	Three unprecedented phloroglucinol-diterpene adducts, chlorabietols A-C (1-3), were isolated from the roots of the rare Chloranthaceae plant Chloranthus oldhamii. They represent a new class of compounds, featuring an abietane-type diterpenoid coupled with different alkenyl phloroglucinol units by forming a 2,3-dihydrofuran ring. Their structures were elucidated by detailed spectroscopic analysis, molecular modeling studies, and electronic circular dichroism calculations. Compounds 1-3 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 12.6, 5.3, and 4.9 mu M, respectively.
资助项目	NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; National Basic Research Program of China (973 Program)[2013CB530700]
WOS关键词	PHOSPHATASE 1B INHIBITORS ; CYSTOPHORA ; METABOLITES ; CONSTITUENTS ; CHEMISTRY ; ALKYL
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000364435000065
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276329]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	Li, Jia
作者单位	1.Inst Bioengn & Nanotechnol, The Nanos 138669, Singapore 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xiong, Juan,Hong, Zhi-Lai,Gao, Li-Xin,et al. Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(21):11080-11085.
APA	Xiong, Juan.,Hong, Zhi-Lai.,Gao, Li-Xin.,Shen, Jie.,Liu, Shu-Ting.,...&Hu, Jin-Feng.(2015).Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii.JOURNAL OF ORGANIC CHEMISTRY,80(21),11080-11085.
MLA	Xiong, Juan,et al."Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii".JOURNAL OF ORGANIC CHEMISTRY 80.21(2015):11080-11085.