Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA

doi:10.1002/smll.201502913

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	Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA
	Wang, Dangge 1,2; Wang, Tingting 1,2; Xu, Zhiai 3; Yu, Haijun1,2 ; Feng, Bing 1,2; Zhang, Junying 3; Guo, Chengyue 1,2; Yin, Qi1,2 ; Zhang, Zhiwen1,2 ; Li, Yaping1,2
刊名	SMALL
	2016-01-27
卷号	12 期号:4 页码:488-498
ISSN号	1613-6810
DOI	10.1002/smll.201502913
文献子类	Article
英文摘要	Conventional chemotherapy shows moderate efficiency against metastatic cancer since it targets only part of the mechanisms regulating tumor growth and metastasis. Here, gold nanorod (GNR)-based host-guest nanoplatforms loaded with docetaxel (DTX) and small interfering RNA (siRNA)-p65 (referred to as DTX-loaded GNR (GDTX)/p65) for chemo-, RNA interference (RNAi), and photothermal ablation (PTA) cooperative treatment of metastatic breast cancer are reported. To prepare the nanoplatform, GNRs are first coated with cyclodextrin (CD)-grafted polyethylenimine (PEI) and then loaded with DTX and siRNA through host-guest interaction with CD and electrostatic interaction with PEI, respectively. Upon near-infrared laser irradiation, GNRs generate a significant hyperthermia effect to trigger siRNA and DTX release. DTX reduces tumor growth by inhibiting mitosis of cancer cells. Meanwhile, siRNA-p65 suppresses lung metastasis and proliferation of cancer cells by blocking the nuclear factor kappa B (NF-kappa B) pathway and downregulating the downstream genes matrix metalloproteinase-9 (MMP-9) and B cell lymphoma-2 (Bcl-2). It is demonstrated that GDTX/p65 in combination with laser irradiation significantly inhibits the growth and lung metastasis of 4T1 breast tumors. The antitumor results suggest promising potential of the host-guest nanoplatform for combinational treatment of metastatic cancer by using RNAi, chemotherapy, and PTA.
资助项目	National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81373359] ; National Natural Science Foundation of China[21305047] ; Youth Innovation Promotion Association Chinese Academy of Sciences[00000000]
WOS关键词	PHOTOTHERMAL THERAPY ; CARBON NANOTUBES ; GOLD NANORODS ; TARGETED DELIVERY ; TUMOR-METASTASIS ; KAPPA-B ; NANOPARTICLES ; CHEMOTHERAPY ; INHIBITION ; EFFICIENT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000368840500009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276175]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yu, Haijun; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.E China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
推荐引用方式 GB/T 7714	Wang, Dangge,Wang, Tingting,Xu, Zhiai,et al. Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA[J]. SMALL,2016,12(4):488-498.
APA	Wang, Dangge.,Wang, Tingting.,Xu, Zhiai.,Yu, Haijun.,Feng, Bing.,...&Li, Yaping.(2016).Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA.SMALL,12(4),488-498.
MLA	Wang, Dangge,et al."Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA".SMALL 12.4(2016):488-498.