ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities

doi:10.1016/j.phytochem.2015.11.014

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities
	Wang, Wen-qiong; Xuan, Li-jiang
刊名	PHYTOCHEMISTRY
	2016-02
卷号	122 页码:119-125
关键词	Rabdosia serra Lamiaceae ent-Kaurane diterpenoids Cytotoxic activity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2015.11.014
文献子类	Article
英文摘要	Investigation of the hydrophobic extract of Rabdosia serra (Lamiaceae) led to the isolation of seven ent-6,7-secokaurane diterpenoids rabdosins E-K, along with twelve known ent-kaurane diterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of rabdosins E, F, H and I were determined by single -crystal X-ray diffraction, with rabdosin E having a 3,20 -epoxy group. These diterpenoids could be divided into two types according to their skeletons: rabdoMns E -J are ent-6,20-epoxy-6,7-secokaur-1,7-olides, and rabdosin K is an ent-6,7-secokaur-7,20-olide. Cytotoxicity evaluation showed that serrin B, serrin A, isodocarpin and lushanrubescensin J exhibited weak to moderate cytotoxic activities (IC50 < 10 mu M) against two human cancer cell lines. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; National Natural Sciences Foundation of China[30901851] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0907 KF-04]
WOS关键词	RUBESCENS VAR. LUSHANENSIS ; ENT-KAURENE DITERPENOIDS ; ABSOLUTE-CONFIGURATION ; KAURANE DITERPENOIDS ; JAPONICUS HARA ; ISODON-SERRA ; CONSTITUENTS ; TERPENOIDS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000369460200012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276165]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xuan, Li-jiang
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wen-qiong,Xuan, Li-jiang. ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities[J]. PHYTOCHEMISTRY,2016,122:119-125.
APA	Wang, Wen-qiong,&Xuan, Li-jiang.(2016).ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities.PHYTOCHEMISTRY,122,119-125.
MLA	Wang, Wen-qiong,et al."ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities".PHYTOCHEMISTRY 122(2016):119-125.