Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker

doi:10.1016/j.tet.2016.01.030

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	Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker
	Tang, Hua 1; Chen, Qi-Feng 1; Liu, Xiao-Yu 1,2; Zhang, Hua 2; Chen, Dong-Lin 1; Wang, Feng-Peng 1
刊名	TETRAHEDRON
	2016-03-10
卷号	72 期号:10 页码:1357-1363
关键词	Diterpenoid alkaloid Natural product Ring distortion Talatisamine
ISSN号	0040-4020
DOI	10.1016/j.tet.2016.01.030
文献子类	Article
英文摘要	Thirteen new analogues of diterpenoid alkaloids were synthesized from the potassium ion channel blocker talatisamine (1) by means of the ring-distortion strategy. Most of these derivatives are unique by featuring differentiated CD rings compared to the corresponding naturally-occurring alkaloids. Remarkable transformations including a novel rearrangement (1 -> 7 and 13 -> 7), an intriguing fragmentation (16 -> 8), together with the preparation of an unprecedented C-homo-o-nor derivative 12, were disclosed in this study. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81273387] ; National Natural Science Foundation of China[21502126] ; State Key Laboratory of Drug Research[SIMM1501KF-11]
WOS关键词	7,17-SECO NORDITERPENOID ALKALOIDS ; DIVERSITY-ORIENTED SYNTHESIS ; NATURAL-PRODUCTS ; C-19-DITERPENOID ALKALOIDS ; DELTALINE ; DISCOVERY ; ACID ; DEMETHYLATION ; HETERATISINE ; CHEMISTRY
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000370906600011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276103]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Liu, Xiao-Yu; Wang, Feng-Peng
作者单位	1.Sichuan Univ, West China Coll Pharm, Dept Chem Med Nat Prod, 17,Duan 3,Renmin Nan Rd, Chengdu 610041, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Tang, Hua,Chen, Qi-Feng,Liu, Xiao-Yu,et al. Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker[J]. TETRAHEDRON,2016,72(10):1357-1363.
APA	Tang, Hua,Chen, Qi-Feng,Liu, Xiao-Yu,Zhang, Hua,Chen, Dong-Lin,&Wang, Feng-Peng.(2016).Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker.TETRAHEDRON,72(10),1357-1363.
MLA	Tang, Hua,et al."Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker".TETRAHEDRON 72.10(2016):1357-1363.