Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer

doi:10.1002/adfm.201601703

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	Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer
	Tang, Shan 2; Meng, Qingshuo 2; Sun, Huiping 1,2; Su, Jinghan 2; Yin, Qi2 ; Zhang, Zhiwen2 ; Yu, Haijun2 ; Chen, Lingli2 ; Chen, Yi2 ; Gu, Wangwen2
刊名	ADVANCED FUNCTIONAL MATERIALS
	2016-09-06
卷号	26 期号:33 页码:6033-6046
ISSN号	1616-301X
DOI	10.1002/adfm.201601703
文献子类	Article
英文摘要	Prolonged circulation, specific and effective uptake by tumor cells, and rapid intracellular drug release are three main factors for the drug delivery systems to win the battle against metastatic breast cancer. In this work, a tumor microenvironment-adaptive nanoparticle co-loading paclitaxel (PTX) and the anti-metastasis siRNA targeting Twist is prepared. The nanoparticle consists of a pH-sensitive core, a cationic shell, and a matrix metalloproteinase (MMP)-cleavable polyethylene glycol (PEG) corona conjugated via a peptide linker. PEG will be cut away by MMPs at the tumor site, which endows the nanoparticle with smaller particle size and higher positive charge, leading to more efficient cellular uptake in tumor cells and higher intra-tumor accumulation of both PTX and siRNA in the 4T1 tumor-bearing mice models compared to the nanoparticles with irremovable PEG. In addition, acid-triggered drug release in endo/lysosomes is achieved through the pH-sensitive core. As a result, the MMP/pH dual-sensitive nanoparticles significantly inhibit tumor growth and pulmonary metastasis. Therefore, this tumor-microenvironment-adaptive nanoparticle can be a promising codelivery vector for effective therapy of metastatic breast cancer due to simultaneously satisfying the requirements of long circulating time, efficient tumor cell targeting, and fast intracellular drug release.
资助项目	National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81230029] ; National Natural Science Foundation of China[81302712] ; Youth Innovation Promotion Association of CAS[2015226]
WOS关键词	AMINO ESTER NANOPARTICLES ; DRUG-DELIVERY ; GENE DELIVERY ; IN-VIVO ; BIODISTRIBUTION ; THERAPEUTICS ; NANOCARRIERS ; DOXORUBICIN ; PEGYLATION ; EXPRESSION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000383609100009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275897]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yin, Qi; Li, Yaping
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Tang, Shan,Meng, Qingshuo,Sun, Huiping,et al. Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(33):6033-6046.
APA	Tang, Shan.,Meng, Qingshuo.,Sun, Huiping.,Su, Jinghan.,Yin, Qi.,...&Li, Yaping.(2016).Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,26(33),6033-6046.
MLA	Tang, Shan,et al."Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 26.33(2016):6033-6046.