beta-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans

doi:10.1021/acs.jnatprod.6b00648

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	beta-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans
	Gao, Lei 1,2,3; Zhang, Rujun 1,2; Lang, Jianfeng 4,5; Ning, Ruonan 1,2,3; Wu, Di 4,5; Chen, Di 4,5; Zhao, Weimin1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2016-12
卷号	79 期号:12 页码:3039-3046
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.6b00648
文献子类	Article
英文摘要	Seventeen beta-dihydroagarofuran-type sesquiterpenes were isolated from the seeds of Celastrus monospermus, and, among them, 15 (1-15) were identified as new natural products. Nine isolates were evaluated for their lifespan-extending effect using the standard model animal nematode Caenorhabditis elegans. As a result, all of the tested compounds prolonged the lifespan of C. elegans when compared to the blank control group (p < 0.0001). Among them, celaspermin E (5) extended the average lifespan and maximum lifespan of C. elegans, with effects similar to those of rapamycin, a positive control that has been found experimentally to delay the aging process of yeasts, worms, fruit flies, and mice.
资助项目	National Natural Science Foundation of China[81473113] ; State Key Laboratory of Drug Research[SIMM1601KF-03] ; NIH Office of Research Infrastructure Programs[P40 OD010440]
WOS关键词	PANICULATUS ; ORBICULATUS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000390832700008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275779]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Chen, Di; Zhao, Weimin
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China; 5.Nanjing Univ, MOE Key Lab Model Anim Dis Study, Model Anim Res Ctr, Nanjing 210061, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Gao, Lei,Zhang, Rujun,Lang, Jianfeng,et al. beta-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(12):3039-3046.
APA	Gao, Lei.,Zhang, Rujun.,Lang, Jianfeng.,Ning, Ruonan.,Wu, Di.,...&Zhao, Weimin.(2016).beta-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans.JOURNAL OF NATURAL PRODUCTS,79(12),3039-3046.
MLA	Gao, Lei,et al."beta-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans".JOURNAL OF NATURAL PRODUCTS 79.12(2016):3039-3046.