D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo

doi:10.1016/j.dyepig.2016.08.054

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo
	Yang, Hao-Yu 1,2,4; Zhang, Jing-Jing 4; Zang, Yi3 ; Zhang, Hai-Yan4 ; Li, Jia3 ; Chen, Guo-Rong 1,2; He, Xiao-Peng 1,2
刊名	DYES AND PIGMENTS
	2017-01
卷号	136 页码:224-228
关键词	Amyloid beta Probe Fluorescence In vivo imaging Alzheimer's disease
ISSN号	0143-7208
DOI	10.1016/j.dyepig.2016.08.054
文献子类	Article
英文摘要	The effective imaging of amyloid beta (A beta) in vivo is important for the diagnosis of All-related diseases such as the Alzheimer's disease (AD). Here we report a donor-acceptor-donor (D-A-D) type fluorogenic probe for the rapid imaging of amyloid beta (A beta) senile plaques in a transgenic mouse brain. The probe that features a dicyanomethylene-4H-pyran (DCM) core shows a concentration-dependent fluorescence enhancement with A beta 42 and A beta 40, which are the main components of A beta fibrils formed in the brain of AD patients. The D-A-D probe can also be used to rapidly sense A beta peptide monomer, oligomer and fibril in an aqueous solution and image the morphologically diverse A beta species by confocal microscopy. In particular, we demonstrate that the probe can be used to rapidly stain A beta senile plaques in the brain of transgenic mice by intravenous injection. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	973 project[2013CB733700] ; Natural Science Foundation of China[21572058] ; Natural Science Foundation of China[21576088] ; Natural Science Foundation of China[81302820] ; Natural Science Foundation of China[81522045] ; National Science and Technology Major Projects[2014ZX09507-002] ; Shanghai Science and Technology Development Funds[14YF1413300] ; Shanghai Rising-Star Program[16QA1401400]
WOS关键词	ALZHEIMERS-DISEASE ; FLUORESCENCE PROBE ; MOUSE-BRAIN ; DEPOSITS ; FLUOROPHORES ; DERIVATIVES
WOS研究方向	Chemistry ; Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000387837200028
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275758]
专题	药理学第二研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心国家新药筛选中心
通讯作者	Zhang, Hai-Yan; Li, Jia; He, Xiao-Peng
作者单位	1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yang, Hao-Yu,Zhang, Jing-Jing,Zang, Yi,et al. D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo[J]. DYES AND PIGMENTS,2017,136:224-228.
APA	Yang, Hao-Yu.,Zhang, Jing-Jing.,Zang, Yi.,Zhang, Hai-Yan.,Li, Jia.,...&He, Xiao-Peng.(2017).D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo.DYES AND PIGMENTS,136,224-228.
MLA	Yang, Hao-Yu,et al."D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo".DYES AND PIGMENTS 136(2017):224-228.