Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions

doi:10.1155/2017/9868694

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	Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions
	Chen, Feng 1; Li, Li 2; Tian, Dan-Dan 3
刊名	BIOMED RESEARCH INTERNATIONAL
	2017
ISSN号	2314-6133
DOI	10.1155/2017/9868694
文献子类	Review
英文摘要	Salvia miltiorrhiza root (Danshen) is widely used in Asia for its cardiovascular benefits and contains both hydrophilic phenolic acids and lipophilic tanshinones, which are believed to be responsible for its therapeutic efficacy. This review summarized the effects of these bioactive components from S. miltiorrhiza roots on pharmacokinetics of comedicated drugs with mechanic insights regarding alterations of protein binding, enzyme activity, and transporter activity based on the published data stemming from both in vitro and in vivo human studies. In vitro studies indicated that cytochrome P450 (CYP450), carboxylesterase enzyme, catechol-O-methyltransferase, organic anion transporter 1 (OAT1) and OAT3, and P-glycoprotein were the major targets involved in S. miltiorrhiza-drug interactions. Lipophilic tanshinones had much more potent inhibitory effects towards CYPs activities compared to hydrophilic phenolic acids, evidenced by much lower K-i. values of the former. Clinical S. miltiorrhiza-drug interaction studies were mainly conducted using CYP1A2 and CYP3A4 probe substrates. In addition, the effects of coexisting components on the pharmacokinetic behaviors of those noted bioactive compounds were also included herein.
资助项目	Specialized Research Fund for the Doctoral Program of Hainan Medical College[00000000] ; National Natural Science Foundation of China[81573828] ; National Natural Science Foundation of China[81460629]
WOS关键词	HUMAN SERUM-ALBUMIN ; TRANSPORTERS 1 SLC22A6 ; TANSHINONE IIA ; ACID-B ; INTESTINAL-ABSORPTION ; HEALTHY-VOLUNTEERS ; PHARMACOKINETIC INTERACTIONS ; DANSHEN EXTRACT ; PLASMA-PROTEIN ; SYSTEMIC EXPOSURE
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000399712000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275722]
专题	上海药物代谢研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tian, Dan-Dan
作者单位	1.Hainan Med Coll, Sch Pharm, Hainan Prov Key Lab R&D Trop Herbs, Haikou 571199, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Washington State Univ, Coll Pharm, Dept Pharmaceut Sci, Spokane, WA 99212 USA
推荐引用方式 GB/T 7714	Chen, Feng,Li, Li,Tian, Dan-Dan. Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions[J]. BIOMED RESEARCH INTERNATIONAL,2017.
APA	Chen, Feng,Li, Li,&Tian, Dan-Dan.(2017).Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions.BIOMED RESEARCH INTERNATIONAL.
MLA	Chen, Feng,et al."Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions".BIOMED RESEARCH INTERNATIONAL (2017).