The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7

doi:10.1016/j.ejmech.2016.11.002

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	The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7
	Zhang, Wen-Ming 1; Yang, Teng 2,4; Pan, Xue-Ying 3,4; Liu, Xin-Lan 1; Lin, Hai-Xia 1; Gao, Zhao-Bing4 ; Yang, Cai-Guang4 ; Cui, Yong-Mei 1,4
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2017-02-15
卷号	127 页码:917-927
关键词	Antistaphylococcal Muitidrug-resistant Synthesis Oxime Dehydroabietic acid
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2016.11.002
文献子类	Article
英文摘要	A series of 7-N-acylaminoethyl/propyloxime derivatives of dehydroabietic acid were synthesized and investigated for their antibacterial activity against Staphylococcus aureus Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108 and NRS-271). Most of the target compounds having trifluoromethyl phenyl/benzyl, halogen-substituted thiophenyl, benzothiophenyl or pyrrolyl moiety exhibited potent in vitro antibacterial activity. Among which, compounds 4m, 4x and 7j showed high antibacterial activity with minimum inhibitory concentration (MIC) values of 1.25-3.13 mu g/mL against five multidrug-resistant S. aureus. (C) 2016 Elsevier Masson SAS. All rights reserved.
资助项目	National Natural Science Foundation of China[81202402] ; National Natural Science Foundation of China[21272154] ; National Natural Science Foundation of China[8161101140] ; State Key Laboratory of Drug Research[SIMM1601KF-11]
WOS关键词	AROMATIC ABIETANE DITERPENOIDS ; CHANNEL-OPENING ACTIVITY ; STAPHYLOCOCCUS-AUREUS ; OPENERS ; DESIGN
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000397172800073
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275630]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yang, Cai-Guang; Cui, Yong-Mei
作者单位	1.Shanghai Univ, Dept Chem, Coll Sci, Innovat Drug Res Ctr, Shanghai 200444, Peoples R China; 2.Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Peoples R China; 3.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wen-Ming,Yang, Teng,Pan, Xue-Ying,et al. The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017,127:917-927.
APA	Zhang, Wen-Ming.,Yang, Teng.,Pan, Xue-Ying.,Liu, Xin-Lan.,Lin, Hai-Xia.,...&Cui, Yong-Mei.(2017).The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,127,917-927.
MLA	Zhang, Wen-Ming,et al."The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 127(2017):917-927.