Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance

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	Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance
	Liu, J; Zhang, HY; Tang, XC; Wang, B ; He, XC ; Bai, DL
刊名	ACTA PHARMACOLOGICA SINICA
	1998-09
卷号	19 期号:5 页码:413-416
关键词	cholinesterase inhibitors cholinesterases huperzine A cerebral cortex erythrocyte membrane scopolamine memory maze learning
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To compare the effects of synthetic and natural (-)-huperzine A (Hup A) on cholinesterase and mouse water maze performance. METHODS: Spectrophotometry was used to determine cholinesterase activity. Mouse water maze was used to evaluate nootropic effect. RESULTS: The IC50 of synthetic Hup A for acetylcholinesterase (AChE) of rat cortex and rat erythrocyte membrane determined in vitro were 64.7 (52.6 - 79.5) and 53.9 (43.6 - 66.6) nmol . L-1, respectively, and for butyrylcholinesterase of rat serum was 53.6 (44.9 - 63.8) mu mol.L-1. Synthetic Hup A 0.12 - 0.48 mg. kg(-1) ig produced a dose-dependent inhibition of brain AChE in mice. Synthetic Hup A 0.05 mg: kg(-1) ig attenuated scopolamine-induced impairment of spatial memory. The efficacy of synthetic Hup A was the same as natural Hup A. CONCLUSION: Synthetic Hup A yielded an in. vitro and in vivo pharmacological profile of activities similar to that of natural Hup A.
WOS关键词	HUPERZINE-A ; ALZHEIMERS-DISEASE ; MEMORY
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000075784800004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274806]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Tang, XC
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Synthet Chem, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Liu, J,Zhang, HY,Tang, XC,et al. Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance[J]. ACTA PHARMACOLOGICA SINICA,1998,19(5):413-416.
APA	Liu, J,Zhang, HY,Tang, XC,Wang, B,He, XC,&Bai, DL.(1998).Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance.ACTA PHARMACOLOGICA SINICA,19(5),413-416.
MLA	Liu, J,et al."Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance".ACTA PHARMACOLOGICA SINICA 19.5(1998):413-416.