Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia

doi:10.1016/S0006-8993(02)02977-3

	Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia
	Wang, LS ; Zhou, J ; Shao, XM ; Tang, XC
刊名	BRAIN RESEARCH
	2002-09-13
卷号	949 期号:1-2 页码:162-170
关键词	huperzine A cholinesterase inhibitor hypoxia-ischeinia Morris water maze CA1 neuron neonatal rat
ISSN号	0006-8993
DOI	10.1016/S0006-8993(02)02977-3
文献子类	Article
英文摘要	The protective effects of huperzine A, a novel acetylcholinesterase inhibitor, on hypoxic-ischemc (111) brain injury were investigated in neonatal rats. A unilateral HI brain injury was produced by the ligation of left common carotid artery followed by I h hypoxia with 7.7% oxygen in 7-day-old rat pups. After 5 weeks, HI brain injury in rat pups resulted in working memory impairments shown by increased escape latency in a water maze and reduced time spent in the target quadrant. The combination of common carotid artery ligation and exposure to a hypoxic environment caused the damage in the striatum, cortex, and hippocampus in the ipsilateral hemisphere, and the neuronal loss in the CA1 region. Huperzine A was administrated daily at the dose of 0.05 or 0.1 mg/ kg i.p. for 5 weeks after HI injury. The significant protection against HI injury on behavior and neuropathology was produced by huperzine A at the dose of 0.1 mg/kg. These findings suggest that huperzine A might be beneficial in the treatment of hypoxic-ischemic encephalopathy in neonates. (C) 2002 Elsevier Science B.V. All rights reserved.
WOS关键词	PC12 CELLS ; MEMORY ; PROTECTS ; DAMAGE ; HIPPOCAMPAL ; PERFORMANCE ; IMPAIRMENT ; TACRINE
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000178316900019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274328]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tang, XC
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Fudan Univ, Childrens Hosp, Dept Pediat, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Wang, LS,Zhou, J,Shao, XM,et al. Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia[J]. BRAIN RESEARCH,2002,949(1-2):162-170.
APA	Wang, LS,Zhou, J,Shao, XM,&Tang, XC.(2002).Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia.BRAIN RESEARCH,949(1-2),162-170.
MLA	Wang, LS,et al."Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia".BRAIN RESEARCH 949.1-2(2002):162-170.