Reliability of phototoxic tests of fluoroquinolones in vitro

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	Reliability of phototoxic tests of fluoroquinolones in vitro
	Zhang, T; Li, JL; Ma, XC; Xin, J; Tu, ZH
刊名	ACTA PHARMACOLOGICA SINICA
	2003-05
卷号	24 期号:5 页码:453-459
关键词	phototoxicity fluoroquinolones lomefloxacin sparfloxacin
ISSN号	1671-4083
文献子类	Article
英文摘要	Aim: To make sure the reliability of phototoxic tests in vitro by comparing the phototoxic potential of 4 fluoroquinolones (FQ). Methods: Lomefloxacin (LFLX), sparfloxacin (SPFX), ciprofloxacin (CPFX), and norfloxacin (NFLX) were tested by Wistar rat phototoxic test and Balb/c mouse phototoxic test in vivo, and Chinese hamster V79 cell micronucleus test and NIH 3T3 MTT test in vitro under the different condition of UVA irradiation. Results: In all experiments, LFLX and SPFX showed higher phototoxic potential compared with the control (P<0.01 vs 1% CMC), CPFX was mild (P<0.05 vs physiological saline), NFLX did not show phototoxicity in vivo, however at a higher concentration (10 mumol/L) in vitro, it also induced phototoxicity as other FQ. Conclusion: There are good correlations between phototoxic tests in vivo and in vitro. These results ensure the validation of phototoxic tests in vitro.
WOS关键词	QUINOLONE ANTIBACTERIAL AGENT ; HAMSTER V79 CELLS ; METHOXY GROUP ; SKIN ; OXYGEN ; MICE ; PHOTOGENOTOXICITY ; 8-POSITION ; FUTURE ; PAST
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:1488286
出版者	SHANGHAI INST MATERIA MEDICA
WOS记录号	WOS:000182553500013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274237]
专题	药物安全性评价中心中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第三研究室
通讯作者	Tu, ZH
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhang, T,Li, JL,Ma, XC,et al. Reliability of phototoxic tests of fluoroquinolones in vitro[J]. ACTA PHARMACOLOGICA SINICA,2003,24(5):453-459.
APA	Zhang, T,Li, JL,Ma, XC,Xin, J,&Tu, ZH.(2003).Reliability of phototoxic tests of fluoroquinolones in vitro.ACTA PHARMACOLOGICA SINICA,24(5),453-459.
MLA	Zhang, T,et al."Reliability of phototoxic tests of fluoroquinolones in vitro".ACTA PHARMACOLOGICA SINICA 24.5(2003):453-459.