Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease

doi:10.1016/j.tips.2006.10.004

	Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease
	Zhang, Hai Yan; Tang, Xi Can
刊名	TRENDS IN PHARMACOLOGICAL SCIENCES
	2006-12
卷号	27 期号:12 页码:619-625
ISSN号	0165-6147
DOI	10.1016/j.tips.2006.10.004
文献子类	Review
英文摘要	In recent years, the most common pharmacological treatment for Alzheimer's disease (AD) has been acetylcholinesterase (ACNE) inhibition. However, this single-target approach has limited effectiveness and there is evidence that a multitarget approach might be more effective. Huperzine A (HupA), a novel alkaloid isolated from a Chinese herb, has neuroprotective effects that go beyond the inhibition of ACNE. Recent data have demonstrated that HupA can ameliorate the learning and memory deficiency in animal models and AD patients. Its potentially beneficial actions include modification of beta-amyloid peptide processing, reduction of oxidative stress, neuronal protection against apoptosis, and regulation of the expression and secretion of nerve growth factor (NGF) and NGF signaling.
WOS关键词	AMYLOID PRECURSOR PROTEIN ; RAT PHEOCHROMOCYTOMA CELLS ; NERVE GROWTH-FACTOR ; MUSCARINIC ACETYLCHOLINE-RECEPTORS ; DISSOCIATED HIPPOCAMPAL-NEURONS ; INDUCED OXIDATIVE INJURY ; SWEDISH MUTANT-CELLS ; ALZHEIMERS-DISEASE ; CORTICAL-NEURONS ; NEURITE OUTGROWTH
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE LONDON
WOS记录号	WOS:000242680400003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273440]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第二研究室
通讯作者	Tang, Xi Can
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hai Yan,Tang, Xi Can. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2006,27(12):619-625.
APA	Zhang, Hai Yan,&Tang, Xi Can.(2006).Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease.TRENDS IN PHARMACOLOGICAL SCIENCES,27(12),619-625.
MLA	Zhang, Hai Yan,et al."Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease".TRENDS IN PHARMACOLOGICAL SCIENCES 27.12(2006):619-625.