Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis

doi:10.1007/s12041-007-0004-0

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	Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis
	Du, Jianchang ; Wang, Xingna ; Zhang, Mingsheng ; Tian, Dacheng ; Yang, Yong-Hua
刊名	JOURNAL OF GENETICS
	2007-04
卷号	86 期号:1 页码:27-35
关键词	ankyrin gene cluster divergence evolution gene duplication Arabidopsis
ISSN号	0022-1333
DOI	10.1007/s12041-007-0004-0
文献子类	Article
英文摘要	The ankyrin (ANK) gene cluster is a part of a multigene family encoding ANK transmembrane proteins in Arabidopsis thaliana, and plays an important role in protein-protein interactions and in signal pathways. In contrast to other regions of a genome, the ANK gene cluster exhibits an extremely high level of DNA polymorphism in an similar to 5-kb region, without apparent decay. Phylogenetic analysis detects two clear, deeply differentiated haplotypes (dimorphism). The divergence between haplotypes of accession Col-0 and Ler-0 (Hap-C and Hap-L) is estimated to be 10.7%, approximately equal to the 10.5% average divergence between A. thaliana and A. lyrata. Sequence comparisons for the ANK gene cluster homologues in Col-0 indicate that the members evolve independently, and that the similarity among paralogues is lower than between alleles. Very little intralocus recombination or gene conversion is detected in ANK regions. All these characteristics of the ANK gene cluster are consistent with a tandem gene duplication and birth-and-death process. The possible mechanisms for and implications of this elevated nucleotide variation are also discussed, including the suggestion of balancing selection.
WOS关键词	DEATH PROCESS ; DNA POLYMORPHISM ; PURIFYING SELECTION ; MULTIGENE FAMILIES ; RESISTANCE GENES ; EVOLUTION ; THALIANA ; LOCUS ; RECOMBINATION ; DIVERGENCE
WOS研究方向	Genetics & Heredity
语种	英语
出版者	INDIAN ACADEMY SCIENCES
WOS记录号	WOS:000248375900004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273295]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Yang, Yong-Hua
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Discovery & Design, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nanjing Univ, Dept Biol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
推荐引用方式 GB/T 7714	Du, Jianchang,Wang, Xingna,Zhang, Mingsheng,et al. Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis[J]. JOURNAL OF GENETICS,2007,86(1):27-35.
APA	Du, Jianchang,Wang, Xingna,Zhang, Mingsheng,Tian, Dacheng,&Yang, Yong-Hua.(2007).Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis.JOURNAL OF GENETICS,86(1),27-35.
MLA	Du, Jianchang,et al."Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis".JOURNAL OF GENETICS 86.1(2007):27-35.