COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression

doi:10.1016/j.jneuroim.2007.03.012

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	COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression
	Ni, Jia ; Shu, Ying-Yi ; Zhu, Yi-Na ; Fu, Yun-Feng ; Tang, Wei; Zhong, Xiang-Gen ; Wang, Hui ; Yang, Yi-Fu ; Ren, Jin; Wang, Ming-Wei
刊名	JOURNAL OF NEUROIMMUNOLOGY
	2007-05
卷号	186 期号:1-2 页码:94-103
关键词	Rofecoxib Lumiracoxib experimental autoimmune encephalomyelitis T cell cytokine
ISSN号	0165-5728
DOI	10.1016/j.jneuroim.2007.03.012
文献子类	Article
英文摘要	The COX-2 inhibitors Rofecoxib (Rof) and Lumiracoxib (Lum) were evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). Administration of Rof and Lum significantly reduced the incidence and severity of EAE, which was associated with the inhibition of MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses, and modulation of cytokines production. In vitro Rof and Lum inhibited primary T cells proliferation and modulated cytokine production. These findings highlight the fact that Rof and Lum likely prevents EAE by modulating Th1/Th2 response, and suggest its utility in the treatment of MS and other autoimmune diseases. (c) 2007 Elsevier B.V. All rights reserved.
WOS关键词	EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; CENTRAL-NERVOUS-SYSTEM ; MULTIPLE-SCLEROSIS ; INTERFERON-GAMMA ; REDUCTASE INHIBITOR ; LINEAGE COMMITMENT ; CELL POPULATION ; MICE ; DISEASE ; INDUCTION
WOS研究方向	Immunology ; Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000247452700010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273273]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Wang, Ming-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Ctr Drug Safety Evaluat & Res, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ni, Jia,Shu, Ying-Yi,Zhu, Yi-Na,et al. COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression[J]. JOURNAL OF NEUROIMMUNOLOGY,2007,186(1-2):94-103.
APA	Ni, Jia.,Shu, Ying-Yi.,Zhu, Yi-Na.,Fu, Yun-Feng.,Tang, Wei.,...&Zuo, Jian-Ping.(2007).COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.JOURNAL OF NEUROIMMUNOLOGY,186(1-2),94-103.
MLA	Ni, Jia,et al."COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression".JOURNAL OF NEUROIMMUNOLOGY 186.1-2(2007):94-103.