COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression | |
Ni, Jia; Shu, Ying-Yi; Zhu, Yi-Na; Fu, Yun-Feng; Tang, Wei![]() ![]() ![]() | |
刊名 | JOURNAL OF NEUROIMMUNOLOGY
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2007-05 | |
卷号 | 186期号:1-2页码:94-103 |
关键词 | Rofecoxib Lumiracoxib experimental autoimmune encephalomyelitis T cell cytokine |
ISSN号 | 0165-5728 |
DOI | 10.1016/j.jneuroim.2007.03.012 |
文献子类 | Article |
英文摘要 | The COX-2 inhibitors Rofecoxib (Rof) and Lumiracoxib (Lum) were evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). Administration of Rof and Lum significantly reduced the incidence and severity of EAE, which was associated with the inhibition of MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses, and modulation of cytokines production. In vitro Rof and Lum inhibited primary T cells proliferation and modulated cytokine production. These findings highlight the fact that Rof and Lum likely prevents EAE by modulating Th1/Th2 response, and suggest its utility in the treatment of MS and other autoimmune diseases. (c) 2007 Elsevier B.V. All rights reserved. |
WOS关键词 | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; CENTRAL-NERVOUS-SYSTEM ; MULTIPLE-SCLEROSIS ; INTERFERON-GAMMA ; REDUCTASE INHIBITOR ; LINEAGE COMMITMENT ; CELL POPULATION ; MICE ; DISEASE ; INDUCTION |
WOS研究方向 | Immunology ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000247452700010 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/273273] ![]() |
专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
通讯作者 | Wang, Ming-Wei |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Ctr Drug Safety Evaluat & Res, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Ni, Jia,Shu, Ying-Yi,Zhu, Yi-Na,et al. COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression[J]. JOURNAL OF NEUROIMMUNOLOGY,2007,186(1-2):94-103. |
APA | Ni, Jia.,Shu, Ying-Yi.,Zhu, Yi-Na.,Fu, Yun-Feng.,Tang, Wei.,...&Zuo, Jian-Ping.(2007).COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.JOURNAL OF NEUROIMMUNOLOGY,186(1-2),94-103. |
MLA | Ni, Jia,et al."COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression".JOURNAL OF NEUROIMMUNOLOGY 186.1-2(2007):94-103. |
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