Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha

doi:10.1097/WNR.0b013e3280c1e28c

	Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha
	Yan, Han; Zhang, Hai Yan; Tang, Xi Can
刊名	NEUROREPORT
	2007-05-07
卷号	18 期号:7 页码:689-692
关键词	amyloid precursor protein huperzine A MI-muscarinic acetylcholine receptor mitogen-activated protein kinase protein kinase C
ISSN号	0959-4965
DOI	10.1097/WNR.0b013e3280c1e28c
文献子类	Article
英文摘要	This study is to explore the involvement of muscarinic acetylcholine receptors/protein kinase C cascade and the mitogen-activated protein kinase pathway in the effect of huperzine A on the secretory amyloid precursor protein-alpha. Upregulation of secretory amyloid precursor protein-a by huperzine A was attenuated by muscarinic acetylcholine receptor antagonist (specifically by MI-muscarinic acetylcholine receptor antagonist), and markedly blocked (-377%) by protein kinase C inhibitor as well. Meanwhile, huperzine A can activate the phosphorylation of mitogen-activated protein kinase and, accordingly, partly restored PD98059-decreased secretory amyloid precursor protein-alpha secretion. In addition, huperzine A largely inhibited (-55.4%) acetylcholinesterase activity of the cell line. Our results suggest that activated MI-muscarinic acetylcholine receptor/protein kinase C pathway and mitogen-activated protein kinase signaling are involved in the process of huperzine A enhancing the secretory amyloid precursor protein-alpha secretion.
WOS关键词	ALZHEIMERS-DISEASE ; IN-VITRO ; LEVEL ; AGONISTS ; CELLS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000245856000014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273260]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tang, Xi Can
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yan, Han,Zhang, Hai Yan,Tang, Xi Can. Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha[J]. NEUROREPORT,2007,18(7):689-692.
APA	Yan, Han,Zhang, Hai Yan,&Tang, Xi Can.(2007).Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.NEUROREPORT,18(7),689-692.
MLA	Yan, Han,et al."Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha".NEUROREPORT 18.7(2007):689-692.