Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway

doi:10.1002/ptr.2340

	Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway
	Ruan Min 1; Ji Tong 1; Yang Wenjun 1; Duan Wenhu2 ; Zhou Xiaojian 1; He Jiacai 3; Zhou Jian 3; Chen Wantao 1; Zhang Chenping 1
刊名	PHYTOTHERAPY RESEARCH
	2008-03
卷号	22 期号:3 页码:407-415
关键词	Shikonin oral squamous cell carcinoma (OSCC) growth inhibition apoptosis NF-kappa B caspase family
ISSN号	0951-418X
DOI	10.1002/ptr.2340
文献子类	Article
英文摘要	Shikonin, a naphthoquinone pigment isolated from the Chinese herbal therapeutic, Zicao, has been shown to exhibit antioxidant and anticancer effects. In this study, its ability to induce apoptosis in cultured Tca-8113 oral cancer cells was studied. Treatment of the Tca-8113 cells with a variety of concentrations of Shikonin (1040 gm) resulted in dose- and time-dependent sequences of events marked by apoptosis, as shown by the loss of cell viability, chromatin condensation, internucleosomal DNA fragmentation and sub-G1 phase accumulation. Furthermore, apoptosis in the Tca-8113 cells was accompanied by the activation of protease caspase-8, -9, -3 and low expression of Bcl-2 protein. Interestingly, inactivation of the NF-kappa B pathway was found in shikonin-induced apoptosis in Tca-8113 cells. These results raise the possibility that the anti-tumor effects of Shikonin in Tca-8113 cells are at least partly through the inactivation of the NF-kappa B pathway and subsequent activation of protease caspase family. Pharmacological inhibition of the NF-kappa B activity by Shikonin might be a powerful treatment option for OSCC in which activation of NF-kappa B plays a critical role in tumor growth and progression. Copyright (C) 2007 John Wiley & Sons, Ltd.
WOS关键词	NATURAL-PRODUCTS ; CANCER STATISTICS ; GENE-EXPRESSION ; BCL-2 FAMILY ; TUMOR-GROWTH ; ACTIVATION ; ANGIOGENESIS ; SURVIVAL ; THERAPY ; ALPHA
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000254481000023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272969]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang Chenping
作者单位	1.Shanghai Jiao Tong Univ, Coll Med, Dept Oral & Maxillofacial Surg, Affiliated Peoples Hosp 9, Shanghai 200011, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 3.Anhui Med Univ, Coll Stomatol, Dept Oral & Maxillofacial Surg, Hefei 230032, Peoples R China
推荐引用方式 GB/T 7714	Ruan Min,Ji Tong,Yang Wenjun,et al. Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway[J]. PHYTOTHERAPY RESEARCH,2008,22(3):407-415.
APA	Ruan Min.,Ji Tong.,Yang Wenjun.,Duan Wenhu.,Zhou Xiaojian.,...&Zhang Chenping.(2008).Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway.PHYTOTHERAPY RESEARCH,22(3),407-415.
MLA	Ruan Min,et al."Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway".PHYTOTHERAPY RESEARCH 22.3(2008):407-415.