Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway

doi:10.1016/j.chembiol.2008.01.013

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	Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
	Tan, Min-Jia2 ; Ye, Ji-Ming 1; Turner, Nigel 1; Hohnen-Behrens, Cordula 1; Ke, Chang-Qiang2 ; Tang, Chun-Ping2 ; Chen, Tong 2; Weiss, Hans-Christoph 3; Gesing, Ernst-Rudolf 4; Rowland, Alex 1
刊名	CHEMISTRY & BIOLOGY
	2008-03
卷号	15 期号:3 页码:263-273
ISSN号	1074-5521
DOI	10.1016/j.chembiol.2008.01.013
文献子类	Article
英文摘要	Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia). These compounds and their aglycones exhibited a number of biologic effects beneficial to diabetes and obesity. In both L6 myotubes and 3T3-L1 adipocytes, they stimulated GLUT4 translocation to the cell membrane-an essential step for inducible glucose entry into cells. This was associated with increased activity of AM P-activated protein kinase (AMPK), a key pathway mediating glucose uptake and fatty acid oxidation. Furthermore, momordicoside(s) enhanced fatty acid oxidation and glucose disposal during glucose tolerance tests in both insulin-sensitive and insulin-resistant mice. These findings indicate that cucurbitane triterpenoids, the characteristic constituents of M. charantia, may provide leads as a class of therapeutics for diabetes and obesity.
WOS关键词	MOMORDICA-CHARANTIA L ; CUCURBITANE-TYPE TRITERPENES ; PROTEIN-KINASE ; IMMATURE FRUITS ; DRUG DISCOVERY ; INSULIN ACTION ; GLYCOSIDES ; CONSTITUENTS ; METFORMIN ; MECHANISM
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000254570500012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272964]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室化学蛋白质组学研究中心
通讯作者	James, David E.
作者单位	1.Univ New S Wales, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key lab Drug Res, Shanghai 201203, Peoples R China; 3.Bayer Ind Serv GmbH & Co, D-51368 Leverkusen, Germany; 4.Bayer CropSci AG, R&D, Ctr Agr, D-40789 Monheim, Germany
推荐引用方式 GB/T 7714	Tan, Min-Jia,Ye, Ji-Ming,Turner, Nigel,et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway[J]. CHEMISTRY & BIOLOGY,2008,15(3):263-273.
APA	Tan, Min-Jia.,Ye, Ji-Ming.,Turner, Nigel.,Hohnen-Behrens, Cordula.,Ke, Chang-Qiang.,...&Yel, Yang.(2008).Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.CHEMISTRY & BIOLOGY,15(3),263-273.
MLA	Tan, Min-Jia,et al."Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway".CHEMISTRY & BIOLOGY 15.3(2008):263-273.